D-DESTHIOBIOTIN

Base Information

• Chemical Name: D-DESTHIOBIOTIN
• CAS No.: 636-20-4
• Molecular Formula: C₁₀H₁₈N₂O₃
• Molecular Weight: 214.265
• Mol file: 636-20-4.mol

Synonyms:5a-Androst-3-en-17-one;dl-dethiobiotine;

Chemical Property of D-DESTHIOBIOTIN

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 166 °C
• Boiling Point: 476.39°C at 760 mmHg
• PKA: 4.77±0.10(Predicted)
• Flash Point: 241.912°C
• PSA: 78.43000
• Density: 1.096g/cm³
• LogP: 1.74900
• Storage Temp.: 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

rac-DesthioBiotin ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: D-DESTHIOBIOTIN is useful as an intermediate in the synthesis of Biotin. The conversion of Dethiobiotin into Biotin was studied in Escherichia coli by starting from specifically deuterated precursors. rac-Desthiobiotin is useful as an intermediate in the synthesis of Biotin. The conversion of Dethiobiotin into Biotin was studied in Escherichia coli by starting from specifically deuterated precursors.

Technology Process of D-DESTHIOBIOTIN

There total 31 articles about D-DESTHIOBIOTIN which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

dl-dethiobiotinol → dl-dethiobiotine (533-48-2,636-20-4,15720-25-9,34879-36-2,41625-34-7)

Guidance literature:

With oxygen; sodium hydrogencarbonate; platinum(IV) oxide; for 48h;

Reference yield:

6-(5-methyl-2-oxo-2,3-dihydro-1H-imidazol-4-yl)-hexanoic acid (4793-80-0) → (+/-)-6-(5t-methyl-2-oxo-imidazolidin-4r-yl)-hexanoic acid (533-48-2,636-20-4,15720-25-9,34879-36-2,41625-34-7) + dl-dethiobiotine (533-48-2,636-20-4,15720-25-9,34879-36-2,41625-34-7)

Guidance literature:

With nickel; sodium carbonate; at 100 ℃; under 117681 Torr; Hydrogenation_.pH ca. 7.5;

DOI:10.1002/hlca.660280174 DOI:10.1002/hlca.19460290402 DOI:10.1021/ja01218a021 DOI:10.1021/ja01209a036

Reference yield:

6-(5-methyl-2-oxo-2,3-dihydro-1H-imidazol-4-yl)-hexanoic acid (4793-80-0) → (+/-)-6-(5t-methyl-2-oxo-imidazolidin-4r-yl)-hexanoic acid (533-48-2,636-20-4,15720-25-9,34879-36-2,41625-34-7) + dl-dethiobiotine (533-48-2,636-20-4,15720-25-9,34879-36-2,41625-34-7)

Guidance literature:

With nickel; sodium carbonate; at 100 ℃; under 117681 Torr; Hydrogenation_.pH ca. 7.5;

DOI:10.1002/hlca.660280174 DOI:10.1002/hlca.19460290402 DOI:10.1021/ja01218a021 DOI:10.1021/ja01209a036

upstream raw materials:

6-(5-methyl-2-oxo-2,3-dihydro-1H-imidazol-4-yl)-hexanoic acid

7,8-diamino-nonanoic acid ethyl ester

6-bromo-hexanoic acid ethyl ester

2-amino-octanedioic acid

Refernces

• 1、 Jouany, Marc,Coustal, Suzy,Frappier, Francois,Marquet, Andree. "Nouvelle synthese de la dethiobiotine". . p. 1301 - 1309. Retrieved 2007/10/02.