(S)-(((1-(6-aMino-9H-purin-9-yl)propan-2-yloxy)Methyl)phosphoryl)bis(oxy)bis(Methylene) isopropyl dicarbonate fuMarate

Base Information

• Chemical Name: (S)-(((1-(6-aMino-9H-purin-9-yl)propan-2-yloxy)Methyl)phosphoryl)bis(oxy)bis(Methylene) isopropyl dicarbonate fuMarate
• CAS No.: 1432630-26-6
• Molecular Formula: C20H22N5O16P
• Molecular Weight: 619.386341
• Mol file: 1432630-26-6.mol

Synonyms:(S)-(((1-(6-aMino-9H-purin-9-yl)propan-2-yloxy)Methyl)phosphoryl)bis(oxy)bis(Methylene) isopropyl dicarbonate fuMarate;Tenofovir disoproxil fumarate-S

Chemical Property of (S)-(((1-(6-aMino-9H-purin-9-yl)propan-2-yloxy)Methyl)phosphoryl)bis(oxy)bis(Methylene) isopropyl dicarbonate fuMarate

Chemical Property:

Purity/Quality:

98%,99%, ^*data from raw suppliers

(S)-TenofovirDisoproxilFumarate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Uses: The S-enantiomeric impurity of the antiviral Tenofovir Disoproxil Fumarate (T018505(P)), which is an acyclic phosphonate nucleotide analogue; reverse transcriptase inhibitor and used as an anti-HIV agent.Tenofovir Disoproxil USP Related Compound A.

Technology Process of (S)-(((1-(6-aMino-9H-purin-9-yl)propan-2-yloxy)Methyl)phosphoryl)bis(oxy)bis(Methylene) isopropyl dicarbonate fuMarate

There total 25 articles about (S)-(((1-(6-aMino-9H-purin-9-yl)propan-2-yloxy)Methyl)phosphoryl)bis(oxy)bis(Methylene) isopropyl dicarbonate fuMarate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.4%

(2E)-but-2-enedioic acid (110-17-8,26099-09-2) + tenofovir disoproxil (201341-05-1) → tenofovir disoproxyl fumarate (202138-50-9,1432630-26-6)

Guidance literature:

In isopropyl alcohol; at 50 - 55 ℃;

Reference yield: 90.0%

chloromethyl isopropyl carbonate (35180-01-9) + (2E)-but-2-enedioic acid (110-17-8,26099-09-2) + tenofovir (147127-20-6) → tenofovir disoproxyl fumarate (202138-50-9,1432630-26-6)

Guidance literature:

tenofovir; With triethylamine; In 1-methyl-pyrrolidin-2-one; at 63 ℃; for 0.5h;

chloromethyl isopropyl carbonate; In 1-methyl-pyrrolidin-2-one; at 63 ℃; for 4h;

(2E)-but-2-enedioic acid; In isopropyl alcohol; at 50 ℃; for 0.5h; Concentration;

Reference yield: 88.2%

(2E)-but-2-enedioic acid (110-17-8,26099-09-2) + tenofovir disoproxil (201341-05-1) → tenofovir disoproxil fumarate (1432630-26-6)

Guidance literature:

In isopropyl alcohol; at 60 ℃; for 2h;

upstream raw materials:

(2E)-but-2-enedioic acid

tenofovir disoproxil

adenine

(R)-9-(2-hydroxypropyl)adenine

Downstream raw materials:

tenofovir disoproxil

Refernces

• 1、 -. "Synthesis process of antiviral drug". . . Retrieved 2020/11/26.
• 2、 -. "Method for preparing tenofovir disoproxil". Paragraph 0024-0028. . Retrieved 2020/01/03.