2-(2,5-difluorophenyl)cyclopropanecarboxylic acid

Base Information

• Chemical Name: 2-(2,5-difluorophenyl)cyclopropanecarboxylic acid
• CAS No.: 1157698-34-4
• Molecular Formula: C₁₀H₈F₂O₂
• Molecular Weight: 198.169
• Hs Code.: 2916399090
• Mol file: 1157698-34-4.mol

Synonyms:2-(2,5-difluorophenyl)cyclopropanecarboxylic acid

Chemical Property of 2-(2,5-difluorophenyl)cyclopropanecarboxylic acid

Chemical Property:

• PSA: 37.30000
• LogP: 2.15290

Purity/Quality:

98%min ^*data from raw suppliers

2-(2,5-Difluorophenyl)cyclopropane-1-carboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(2,5-difluorophenyl)cyclopropanecarboxylic acid

There total 2 articles about 2-(2,5-difluorophenyl)cyclopropanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(2,5-difluoro-phenyl)-cyclopropanecarboxylic acid methoxy-methyl-amide → 2-(2,5-difluoro-phenyl)-cyclopropanecarboxylic acid (1157698-34-4,701914-06-9)

Guidance literature:

2-(2,5-difluoro-phenyl)-cyclopropanecarboxylic acid methoxy-methyl-amide; With sodium hydroxide; In methanol; water; for 3h; Heating / reflux;

With hydrogenchloride; In water;

Reference yield:

3-(2,5-difluoro-phenyl)-N-methoxy-N-methyl-acrylamide (701914-04-7) → 2-(2,5-difluoro-phenyl)-cyclopropanecarboxylic acid (1157698-34-4,701914-06-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: sodium hydride / DMF (N,N-dimethyl-formamide) / 0.5 h / 0 - 20 °C

1.2: 2 h / 0 - 20 °C

2.1: sodium hydroxide / methanol; water / 3 h / Heating / reflux

With sodium hydroxide; sodium hydride; In methanol; DMF (N,N-dimethyl-formamide); water;

upstream raw materials:

3-(2,5-difluoro-phenyl)-N-methoxy-N-methyl-acrylamide

Refernces