S-1-Pyrrolidinecarboxylic acid, 2-(6-bromo-1H-benzimidazol-2-yl)-, 1,1-dimethyleth

Base Information

• Chemical Name: S-1-Pyrrolidinecarboxylic acid, 2-(6-bromo-1H-benzimidazol-2-yl)-, 1,1-dimethyleth
• CAS No.: 1208007-67-3
• Molecular Formula: C16H20BrN3O2
• Molecular Weight: 366.258
• Hs Code.: 29332900
• Mol file: 1208007-67-3.mol

Synonyms:S-1-Pyrrolidinecarboxylic acid, 2-(6-bromo-1H-benzimidazol-2-yl)-, 1,1-dimethyleth;(S)-2-(6-broMo-1h-benziMidazol-2-yl)pyrrolidine-1-carboxylic acid tert-butyl ester;2-(6-Bromo-1H-benzimidazol-2-yl)-1-pyrrolidinecarboxylic acid 1,1-dimethylethyl ether;(S)-tert-butyl 2-(6-bromo-1H-benzo[d]imidazol-2-yl)pyrrolidine-1-carboxylate

Chemical Property of S-1-Pyrrolidinecarboxylic acid, 2-(6-bromo-1H-benzimidazol-2-yl)-, 1,1-dimethyleth

Chemical Property:

• PSA: 58.22000
• LogP: 4.33530

Purity/Quality:

98%Min ^*data from raw suppliers

(S)-tert-Butyl2-(6-bromo-1H-benzo[d]imidazol-2-yl)pyrrolidine-1-carboxylate 95% ^*data from reagent suppliers

Safty Information:

• Safety Statements: 24/25

MSDS Files:

Useful:

Technology Process of S-1-Pyrrolidinecarboxylic acid, 2-(6-bromo-1H-benzimidazol-2-yl)-, 1,1-dimethyleth

There total 21 articles about S-1-Pyrrolidinecarboxylic acid, 2-(6-bromo-1H-benzimidazol-2-yl)-, 1,1-dimethyleth which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(2S)-1-tert-butoxycarbonyl-2-(2-amino-4-bromophenylaminoacyl)pyrrolidine (1228553-72-7) → 1,1-dimethylethyl (2S)-2-(5-bromo-1H-benzimidazol-2-yl)-1-pyrrolidinecarboxylate (1208007-67-3)

Guidance literature:

With ammonium acetate; at 90 ℃; for 1h;

Reference yield: 81.0%

1-(tert-butoxycarbonyl)-L-proline (15761-39-4,59433-50-0) + 4-Bromo-benzene-1,2-diamine (1575-37-7) → (S)-tert-butyl 2-(6-bromo-1H-benzo[d]imidazol-2-yl)pyrrolidine-1-carboxylate (1208007-67-3)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; at 0 - 20 ℃; for 4.5h;

Reference yield: 81.0%

1-(tert-butoxycarbonyl)-L-proline (15761-39-4,59433-50-0) + 4-Bromo-benzene-1,2-diamine (1575-37-7) → 1,1-dimethylethyl (2S)-2-(5-bromo-1H-benzimidazol-2-yl)-1-pyrrolidinecarboxylate (1208007-67-3)

Guidance literature:

1-(tert-butoxycarbonyl)-L-proline; 4-Bromo-benzene-1,2-diamine; With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In tetrahydrofuran; at 0 - 20 ℃; for 3.5h;

With acetic acid; at 40 ℃;

upstream raw materials:

1-(tert-butoxycarbonyl)-L-proline

4-Bromo-benzene-1,2-diamine

tert-butyl (S)-2-((2-amino-5-bromophenyl)aminoformyl)pyrrolidine-1-carboxylate

(2S)-1-tert-butoxycarbonyl-2-(2-amino-4-bromophenylaminoacyl)pyrrolidine

Downstream raw materials:

(S)-tert-butyl 2-(6-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)-1Hbenzo[d]imidazol-2-yl)pyrrolidine-1-carboxylate

C₃₆H₄₂N₆O₄

C₄₄H₄₀N₆O₂

tert-butyl (2S)-2-[5-(4-bromophenyl)-1H-benzimidazol-2-yl]pyrrolidine-1-carboxylate

Refernces

• 1、 -. "5,5-FUSED ARYLENE OR HETEROARYLENE HEPATITIS C VIRUS INHIBITORS". Paragraph 0368; 0370. . Retrieved 2018/08/20.
• 2、 -. "HEPATITIS C VIRUS INHIBITORS AND USES THEREOF IN PREPARATION OF DRUGS". . . Retrieved 2017/12/17.