2-Oxazoline, 2-((2-chloroethyl)amino)-, hydrochloride

Base Information

• Chemical Name: 2-Oxazoline, 2-((2-chloroethyl)amino)-, hydrochloride
• CAS No.: 73771-48-9
• Molecular Formula: C5H9ClN2O
• Molecular Weight: 185.0517
• NSC Number: 80350
• DSSTox Substance ID: DTXSID70224150
• Mol file: 73771-48-9.mol

Synonyms:NSC 80350;73771-48-9;2-Oxazoline, 2-((2-chloroethyl)amino)-, hydrochloride;2-Oxazolamine, N-(2-chloroethyl)-4,5-dihydro-, monohydrochloride;2-((2-Chloroethyl)amino)-2-oxazoline hydrochloride;2-[(2-Chloroethyl)amino]-2-oxazoline hydrochloride;C5H9ClN2O.ClH;2-Oxazoline, hydrochloride;C5-H9-Cl-N2-O.Cl-H;DTXSID70224150;NSC80350;NSC-80350;WLN: T5M CO BHJ BM2G &GH;LS-100725;2-Oxazolamine,5-dihydro-, monohydrochloride

Chemical Property of 2-Oxazoline, 2-((2-chloroethyl)amino)-, hydrochloride

Chemical Property:

• Vapor Pressure: 0.000343mmHg at 25°C
• Boiling Point: 319.2°C at 760 mmHg
• Flash Point: 146.9°C
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 184.0170183
• Heavy Atom Count: 10
• Complexity: 116

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COC(=N1)NCCCl.Cl

Technology Process of 2-Oxazoline, 2-((2-chloroethyl)amino)-, hydrochloride

There total 3 articles about 2-Oxazoline, 2-((2-chloroethyl)amino)-, hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-<(2'-chloroethyl)imino>-3-nitroso-2-oxazolidine (76310-08-2) → 2-<(2-chloroethyl)amino>-2-oxazoline hydrochloride (73771-48-9)

Guidance literature:

With hydrogenchloride; In diethyl ether; at 0 - 4 ℃; for 0.5h;

DOI:10.1021/jm00135a007

Reference yield:

1,3-bis(2-chloroethyl)urea (2214-72-4) → 2-<(2-chloroethyl)amino>-2-oxazoline hydrochloride (73771-48-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 72 percent / H₂O / Heating

2: 45 percent / n-butyl nitrite, sodium methoxide / diethyl ether / 12 h / Ambient temperature

3: HCl(g) / diethyl ether / 0.5 h / 0 - 4 °C

With hydrogenchloride; n-Butyl nitrite; sodium methylate; In diethyl ether; water;

DOI:10.1021/jm00135a007

Reference yield:

2-<(2-chloroethyl)amino>-2-oxazoline (71353-16-7) → 2-<(2-chloroethyl)amino>-2-oxazoline hydrochloride (73771-48-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 45 percent / n-butyl nitrite, sodium methoxide / diethyl ether / 12 h / Ambient temperature

2: HCl(g) / diethyl ether / 0.5 h / 0 - 4 °C

With hydrogenchloride; n-Butyl nitrite; sodium methylate; In diethyl ether;

DOI:10.1021/jm00135a007

upstream raw materials:

2-<(2'-chloroethyl)imino>-3-nitroso-2-oxazolidine

1,3-bis(2-chloroethyl)urea

2-<(2-chloroethyl)amino>-2-oxazoline

Refernces