4-Methylbenzophenone-d3

Base Information

• Chemical Name: 4-Methylbenzophenone-d3
• CAS No.: 109339-64-2
• Molecular Formula: C14H10D3O
• Molecular Weight: 200.270905334
• Mol file: 109339-64-2.mol

Synonyms:4-Methylbenzophenone-d3;(4-Methylphenyl-d3)phenylMethanone;(Phenyl)[4-(Methyl-d3)phenyl]Methanone;[4-(Methyl-d3)phenyl]phenylMethanone;4-Benzoyltoluene-d3;4-Methylphenyl-d3 Phenyl Ketone;NSC 4898-d3;p-(Methyl-d3)benzophenone

Chemical Property of 4-Methylbenzophenone-d3

Chemical Property:

• PSA: 17.07000
• LogP: 3.22600
• Storage Temp.: Refrigerator
• Solubility.: Chloroform (Slightly), Methanol (Slightly)

Purity/Quality:

98% ^*data from raw suppliers

4-Methylbenzophenone-d3 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Labelled 4-Methylbenzophenone. Benzophenone estrogenicity toxicity structure activity.

Technology Process of 4-Methylbenzophenone-d3

There total 2 articles about 4-Methylbenzophenone-d3 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

methyl-d3 4-methylbenzenesulfonate (7575-93-1) + p-benzoylphenyl triflate (124643-34-1) → 4-trideuteriomethyl-benzophenone (109339-64-2)

Guidance literature:

With manganese; chloro-trimethyl-silane; salcomine; bis(bipyridine)nickel(II) bromide; In N,N-dimethyl-formamide; at 30 ℃; for 24h; Schlenk technique; Inert atmosphere;

DOI:10.1021/acs.orglett.8b01863

Reference yield:

toluene-d3 (1124-18-1) + benzoyl chloride (98-88-4) → 4-trideuteriomethyl-benzophenone (109339-64-2)

Guidance literature:

With aluminium trichloride;

DOI:10.1021/ja01526a020

Reference yield:

4-trideuteriomethyl-benzophenone (109339-64-2) → 4-trideuteriomethyl-trityl chloride (110535-16-5)

Guidance literature:

Multi-step reaction with 2 steps

1: diethyl ether

2: acetyl chloride

With diethyl ether; acetyl chloride;

DOI:10.1021/ja01526a020

upstream raw materials:

toluene-d3

benzoyl chloride

methyl-d3 4-methylbenzenesulfonate

p-benzoylphenyl triflate

Downstream raw materials:

Diphenyl-(4-trideuteriomethyl-phenyl)-methanol

4-trideuteriomethyl-trityl chloride

Refernces

• 1、 Lin, Yun,Zhu, Lei,Lan, Yu,Rao, Yu. "Development of a Rhodium(II)-Catalyzed Chemoselective C(sp3)-H Oxygenation". supporting information. p. 14937 - 14942. Retrieved 2015/10/19.