Cyclobutanamine hydrochloride

Base Information

• Chemical Name: Cyclobutanamine hydrochloride
• CAS No.: 6291-01-6
• Molecular Formula: C4H10ClN
• Molecular Weight: 107.583
• Hs Code.: 2921300090
• European Community (EC) Number: 228-540-4
• DSSTox Substance ID: DTXSID80978697
• NSC Number: 4598
• Mol file: 6291-01-6.mol

Synonyms:cyclobutanamine hydrochloride;Cyclobutylamine hydrochloride;6291-01-6;cyclobutanamine;hydrochloride;Cyclobutylamine, HCl;MFCD00034953;Aminocyclobutane HCl;Cyclobutanamine, hydrochloride;Cyclobutanamine HCl;cyclobutanaminium chloride;Cyclobutanamine'hydrochloride;SCHEMBL338818;cyclobutylamine hydrochloric acid;cyclobutylamine hydrochloride salt;AMY6177;DTXSID80978697;NSC4598;NFAZOGXQOWEWBM-UHFFFAOYSA-N;Cyclobutylamine hydrochloride, 97%;NSC-4598;AKOS007929999;BP-10291;Cyclobutanamine--hydrogen chloride (1/1);SY013751;CS-0006655;EN300-72090;A901999;F1967-9096;Z1266823158

Chemical Property of Cyclobutanamine hydrochloride

Chemical Property:

• Vapor Pressure: 8.45mmHg at 25°C
• Melting Point: 180-183 °C(lit.
• Boiling Point: 131.3 °C at 760 mmHg
• Flash Point: 33.2 °C
• PSA: 26.02000
• LogP: 1.99990
• Storage Temp.: Inert atmosphere,Room Temperature
• Sensitive.: Hygroscopic
• Water Solubility.: Soluble in water.
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 107.0501770
• Heavy Atom Count: 6
• Complexity: 30.6

Purity/Quality:

98%, ^*data from raw suppliers

Cyclobutylamine hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): F,C
• Hazard Codes: F,C
• Statements: 11-34
• Safety Statements: 16-26-36/37/39-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1CC(C1)N.Cl
• Uses: Cyclobutylamine hydrochloride was used in the preparation of cyclobutylarachidonylamide.

Technology Process of Cyclobutanamine hydrochloride

There total 3 articles about Cyclobutanamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

cyclobutyl amide (1503-98-6) → cyclobutanamine hydrochloride (6291-01-6)

Guidance literature:

cyclobutyl amide; With [bis(acetoxy)iodo]benzene; trifluoroacetic acid; In water; acetonitrile; for 4h;

With hydrogenchloride; In water;

DOI:10.15227/orgsyn.066.0132

Reference yield:

cyclobutylamine (2516-34-9) → cyclobutanamine hydrochloride (6291-01-6)

Guidance literature:

With hydrogenchloride; In dichloromethane;

DOI:10.1021/jacs.0c09403

Reference yield:

→ cyclobutanamine hydrochloride (6291-01-6)

Guidance literature:

upstream raw materials:

cyclobutyl amide

cyclobutylamine

Downstream raw materials:

Cyclopropylmethanol

cyclobutanol

N-cyclobutyl-5-(3-fluorophenylethynyl)picolinamide

N-cyclobutyl-5-((3-fluorophenyl)ethynyl)picolinamide

Refernces

• 1、 Almond, Merrick R.,Stimmel, Julie B.,Thompson, E. Alan,Loudon, G. Marc. "Hofmann rearrangement under mildly acidic conditions using [i,i-bis(trifluoroacetoxy)] iodobenzene: Cyclobutylamine hydrochloride from cyclobutanecarboxamide". . p. 132 - 132. Retrieved 2017/05/20.
• 2、 -. "Synergistic local anesthetic compositions". . . Retrieved 2008/06/13.