2-(Naphthalen-1-yl)-3-phenylpropanoic acid

Base Information

• Chemical Name: 2-(Naphthalen-1-yl)-3-phenylpropanoic acid
• CAS No.: 3776-44-1
• Molecular Formula: C₁₉H₁₆O₂
• Molecular Weight: 276.335
• Mol file: 3776-44-1.mol

Synonyms:2-(Naphthalen-1-yl)-3-phenylpropanoic acid

Chemical Property of 2-(Naphthalen-1-yl)-3-phenylpropanoic acid

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(Naphthalen-1-yl)-3-phenylpropanoic acid

There total 4 articles about 2-(Naphthalen-1-yl)-3-phenylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

1-[(E)-2-nitroethenyl]naphthalene (4735-49-3,37630-26-5) + benzylmagnesium chloride (6921-34-2) → (±)-2-(naphthalen-1-yl)-3-phenylpropanoic acid (3776-44-1)

Guidance literature:

With sulfuric acid; THF, -20 deg C, 10 min; THF, water, 0 deg C, 30 min;

DOI:10.1016/0040-4039(96)01366-4

Reference yield:

→ (±)-2-(naphthalen-1-yl)-3-phenylpropanoic acid (3776-44-1)

Guidance literature:

With sodium hydroxide; nickel; Hydrogenation;

DOI:10.1021/ja01535a059 DOI:10.1007/BF02762513

Reference yield:

→ (±)-2-(naphthalen-1-yl)-3-phenylpropanoic acid (3776-44-1)

Guidance literature:

With potassium hydroxide; benzyl alcohol;

DOI:10.1021/ja01535a059

upstream raw materials:

1-[(E)-2-nitroethenyl]naphthalene

benzylmagnesium chloride

Refernces

• 1、 Yao, Ching-Fa,Kao, Kuo-Hsi,Liu, Ju-Tsung,Chu, Cheng-Ming,Wang, Yeh,Chen, Wen-Chang,Lin, Yu-Mei,Lin, Wen-Wei,Yan, Ming-Chung,Liu, Jing-Yuan,Chuang, Ming-Ching,Shiue, Jin-Lien. "Generation of nitroalkanes, hydroximoyl halides and nitrile oxides from the reactions of β-nitrostyrenes with Grignard or organolithium reagents". . p. 791 - 822. Retrieved 2007/10/03.