8-O-Benzyl CarMoterol Hydrochloride

Base Information

• Chemical Name: 8-O-Benzyl CarMoterol Hydrochloride
• CAS No.: 1052689-06-1
• Molecular Formula: C₂₈H₃₀N₂O₄*ClH
• Molecular Weight: 495.018
• Mol file: 1052689-06-1.mol

Synonyms:8-O-Benzyl CarMoterol Hydrochloride;5-[(1R)-1-Hydroxy-2-[[(1R)-2-(4-Methoxyphenyl)-1-Methylethyl]aMino]ethyl]-8-(phenylMethoxy)-2(1H)-quinolinone Hydrochloride;5-[(1R)-1-Hydroxy-2-[[(1R)-2-(4-methoxyphenyl)-1-methylethyl]amino]ethyl]-8-(phenylmethoxy)-2(1H)-quinolinone hydrochloride (1:)

Chemical Property of 8-O-Benzyl CarMoterol Hydrochloride

Chemical Property:

• PSA: 83.84000
• LogP: 5.97510
• Storage Temp.: Refrigerator
• Solubility.: Methanol (Slightly), Water (Slightly, Sonicated)

Purity/Quality:

97% ^*data from raw suppliers

8-O-BenzylCarmoterolHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Carmoterol (C183750) derivative.

Technology Process of 8-O-Benzyl CarMoterol Hydrochloride

There total 38 articles about 8-O-Benzyl CarMoterol Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.6%

potassium hydoxide-methanol + 8-benzyloxy-5-{(1R)-1-hydroxy-2-[N-((1R)-2-(p-methoxyphenyl)-1-methylethyl)-N-((2S)-1-(2-naphthylsulfonyl)pyrrolidine-2-carbonyl)amino]ethyl}carbostyril → 8-benzyloxy-5-{(1R)-1-hydroxy-2-[N-((lR)-2-(p-methoxy phenyl)-1-methylethyl) amino] ethyl} carbostyril hydrochloride (1052689-06-1)

Guidance literature:

In methanol; water;

Reference yield:

8-benzyloxy-5-{(1R)-1-hydroxy-2-[N-(1R)-2-(p-methoxyphenyl)-1-methylethylamino]ethyl}carbostyril oxalate → 8-benzyloxy-5-{(1R)-1-hydroxy-2-[N-((lR)-2-(p-methoxy phenyl)-1-methylethyl) amino] ethyl} carbostyril hydrochloride (1052689-06-1)

Guidance literature:

8-benzyloxy-5-{(1R)-1-hydroxy-2-[N-(1R)-2-(p-methoxyphenyl)-1-methylethylamino]ethyl}carbostyril oxalate; With sodium hydroxide; water; In dichloromethane;

With hydrogenchloride; In water; isopropyl alcohol; at 10 - 25 ℃; for 15.5h; pH=3 - 4; Product distribution / selectivity; Heating / reflux;

Reference yield:

8-benzyloxy-5-{(1R)-1-hydroxy-2-[N-(1R)-2-(p-methoxyphenyl)-1-methylethylamino]ethyl}carbostyril benzoate → 8-benzyloxy-5-{(1R)-1-hydroxy-2-[N-((lR)-2-(p-methoxy phenyl)-1-methylethyl) amino] ethyl} carbostyril hydrochloride (1052689-06-1)

Guidance literature:

8-benzyloxy-5-{(1R)-1-hydroxy-2-[N-(1R)-2-(p-methoxyphenyl)-1-methylethylamino]ethyl}carbostyril benzoate; With sodium hydroxide; water; In dichloromethane;

With hydrogenchloride; In water; isopropyl alcohol; at 10 - 25 ℃; for 15.5h; pH=3 - 4; Product distribution / selectivity; Heating / reflux;

upstream raw materials:

(R)-5-(2-oxiranyl)-8-benzyloxy-2(1H)-quinolinone

(R)-(+)-N-(1-phenylethyl)-N-[1-(p-methoxyphenyl)-2-propyl]amine hydrochloride

Refernces

• 1、 -. "Bronchodilating 8-hydroxy-5-{(1R)-1-hydroxy-2-[N-((1R)-2-(p-methoxyphenyl)-1-methylethyl)-amino]ethyl} carbostyril". . . Retrieved 2008/06/13.