1,2-Cyclohexanedicarbaldehyde

Base Information

• Chemical Name: 1,2-Cyclohexanedicarbaldehyde
• CAS No.: 51555-65-8
• Molecular Formula: C8H12O2
• Molecular Weight: 140.182
• Mol file: 51555-65-8.mol

Synonyms:1,2-Cyclohexanedicarbaldehyde

Chemical Property of 1,2-Cyclohexanedicarbaldehyde

Chemical Property:

• Boiling Point: 225.5±33.0 °C(Predicted)
• PSA: 34.14000
• Density: 1.172±0.06 g/cm3(Predicted)
• LogP: 1.19060

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,2-Cyclohexanedicarbaldehyde

There total 4 articles about 1,2-Cyclohexanedicarbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1,2-bis(hydroxymethyl)cyclohexane (3971-29-7,25712-33-8) → cyclohexane-1,2-dicarbaldehyde (51555-65-8)

Guidance literature:

1,2-bis(hydroxymethyl)cyclohexane; With oxalyl dichloride; dimethyl sulfoxide; In dichloromethane; at -78 ℃; for 0.5h;

With triethylamine; In dichloromethane; at -78 - 20 ℃;

DOI:10.1016/j.ejmech.2011.09.037

Reference yield:

oxalyl dichloride (79-37-8) + cis-1,2-cyclohexanedimethanol (15753-50-1,25712-33-8) → cyclohexane-1,2-dicarbaldehyde (51555-65-8)

Guidance literature:

With dimethyl sulfoxide; triethylamine; In dichloromethane; water;

Reference yield:

→ cyclohexane-1,2-dicarbaldehyde (51555-65-8)

Guidance literature:

With methanol; palladium on activated charcoal; Hydrogenation;

DOI:10.1021/ja01132a018

upstream raw materials:

cis-1,2-cyclohexanedimethanol

oxalyl dichloride

1,2-bis(hydroxymethyl)cyclohexane

Downstream raw materials:

1-carbomethoxy-2-amino-4,5,6,7-tetrahydro-2H-isoindole

2-[(3R,4R)-3-((S)-1-Benzyloxy-ethyl)-4-methyl-2-methylene-5-oxo-pyrrolidin-1-yl]-4,5,6,7-tetrahydro-2H-isoindole-1-carboxylic acid methyl ester

2-[(2R,3R)-3-((S)-1-Benzyloxy-ethyl)-2-methyl-pent-4-ynoylamino]-4,5,6,7-tetrahydro-2H-isoindole-1-carboxylic acid methyl ester

4,5,6,7-tetrahydro-2H-isoindole

Refernces

• 1、 Jacobi, Peter A.,Buddhu, Subhas C.,Fry, Douglas,Rajeswari. "Studies on the Synthesis of Phytochrome and Related Tetrapyrroles. Dihydropyrromethenones by Photochemical Rearrangement of N-Pyrrolo Enamides". . p. 2894 - 2906. Retrieved 2007/10/03.