4-methyl-5-phenylThiazole

Base Information

• Chemical Name: 4-methyl-5-phenylThiazole
• CAS No.: 19968-61-7
• Molecular Formula: C10H9NS
• Molecular Weight: 175.254
• Mol file: 19968-61-7.mol

Synonyms:4-methyl-5-phenylThiazole

Chemical Property of 4-methyl-5-phenylThiazole

Chemical Property:

• Boiling Point: 134 °C (20 mmHg)
• PSA: 41.13000
• LogP: 3.11850

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-methyl-5-phenylThiazole

There total 13 articles about 4-methyl-5-phenylThiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

4-Methylthiazole (693-95-8) + bromobenzene (108-86-1,52753-63-6) → 4-methyl-5-phenyl-1,3-thiazole (19968-61-7)

Guidance literature:

With C₈₂H₇₇Cl₂N₃O₂Pd; potassium carbonate; Trimethylacetic acid; In N,N-dimethyl acetamide; at 130 ℃; for 4h;

DOI:10.1016/j.jorganchem.2019.06.016

Reference yield: 75.0%

4-Methylthiazole (693-95-8) + iodobenzene (591-50-4) → 4-methyl-5-phenyl-1,3-thiazole (19968-61-7)

Guidance literature:

With palladium(II) trimethylacetate; caesium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 24h; Reagent/catalyst; Temperature; Time; Solvent; regioselective reaction; Schlenk technique; Inert atmosphere;

DOI:10.1021/ol4027073

Reference yield: 74.0%

4-methylthiazole-5-carboxylic acid (20485-41-0) + bromobenzene (108-86-1,52753-63-6) → 4-methyl-5-phenyl-1,3-thiazole (19968-61-7)

Guidance literature:

With tetrabutyl-ammonium chloride; caesium carbonate; bis(tri-t-butylphosphine)palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 170 ℃; for 0.133333h; microwave irradiation;

DOI:10.1021/ja063511f

upstream raw materials:

4-methyl-5-phenyl-2,5-dihydro-thiazole

thiocarboxamide

1-bromo-1-phenyl-2-propanone

4-Methylthiazole

Downstream raw materials:

N-methyl-N-(1-methyl-2-phenyl-ethyl)-N'-phenyl-thiourea

1-(3-bromo-4-ethoxy-phenyl)-3-[4-(4-methyl-thiazol-5-yl)-phenyl]-thiourea

1-(3-bromo-4-methoxy-phenyl)-3-[4-(4-methyl-thiazol-5-yl)-phenyl]-thiourea

1-(3,4-dichloro-phenyl)-3-[4-(4-methyl-thiazol-5-yl)-phenyl]-thiourea

Refernces

• 1、 Maji, Ankur,Singh, Anshu,Mohanty, Aurobinda,Maji, Pradip K.,Ghosh, Kaushik. "Ferrocenyl palladacycles derived from unsymmetrical pincer-type ligands: Evidence of Pd(0) nanoparticle generation during the Suzuki-Miyaura reaction and applications in the direct arylation of thiazoles and isoxazoles". supporting information. p. 17083 - 17096. Retrieved 2019/11/26.
• 2、 He, Xiao-Xi,Li, Yan-Fang,Huang, Ju,Shen, Dong-Sheng,Liu, Feng-Shou. "A convenient phosphine-free palladium-catalyzed direct arylation of thiazole under mild aerobic conditions". . p. 58 - 66. Retrieved 2015/12/30.