2-DIFLUOROMETHYL-PHENOL

Base Information

• Chemical Name: 2-DIFLUOROMETHYL-PHENOL
• CAS No.: 271249-71-9
• Molecular Formula: C₇H₆F₂O
• Molecular Weight: 144.121
• Hs Code.: 2908990000
• Mol file: 271249-71-9.mol

Synonyms:2-DIFLUOROMETHYL-PHENOL

Chemical Property of 2-DIFLUOROMETHYL-PHENOL

Chemical Property:

• Boiling Point: 193.9±30.0 °C(Predicted)
• PSA: 20.23000
• Density: 1.244±0.06 g/cm3(Predicted)
• LogP: 2.32980

Purity/Quality:

2-(DIFLUOROMETHYL)PHENOL 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-(Difluoromethyl)phenol is useful for preparing fungicides.

Technology Process of 2-DIFLUOROMETHYL-PHENOL

There total 3 articles about 2-DIFLUOROMETHYL-PHENOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(benzyloxy)-2-(difluoromethyl)benzene (915799-68-7) → HOC6H4CHF2 (271249-71-9)

Guidance literature:

With hydrogen; acetic acid; palladium dihydroxide; In methanol;

DOI:10.1016/j.bmc.2006.09.002

Reference yield:

salicylaldehyde (90-02-8) → HOC6H4CHF2 (271249-71-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 97 percent / cesium carbonate / dimethylformamide / 6 h / 20 °C

2: 75 percent / DAST / CH₂Cl₂; methanol / 5 h

3: hydrogen; acetic acid / Pd(OH)2/C / methanol

With hydrogen; caesium carbonate; acetic acid; 4,4'-diaminostilbene-2,2'-disulfonic acid; palladium dihydroxide; In methanol; dichloromethane; N,N-dimethyl-formamide;

DOI:10.1016/j.bmc.2006.09.002

Reference yield:

2-(phenylmethoxy)benzaldehyde (5896-17-3) → HOC6H4CHF2 (271249-71-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 75 percent / DAST / CH₂Cl₂; methanol / 5 h

2: hydrogen; acetic acid / Pd(OH)2/C / methanol

With hydrogen; acetic acid; 4,4'-diaminostilbene-2,2'-disulfonic acid; palladium dihydroxide; In methanol; dichloromethane;

DOI:10.1016/j.bmc.2006.09.002

upstream raw materials:

1-(benzyloxy)-2-(difluoromethyl)benzene

salicylaldehyde

2-(phenylmethoxy)benzaldehyde

Refernces