3-CYANOBENZALDEHYDE OXIME

Base Information

• Chemical Name: 3-CYANOBENZALDEHYDE OXIME
• CAS No.: 64847-76-3
• Molecular Formula: C8H6N2O
• Molecular Weight: 146.148
• Hs Code.: 2928000090
• Mol file: 64847-76-3.mol

Synonyms:3-CYANOBENZALDEHYDE OXIME

Chemical Property of 3-CYANOBENZALDEHYDE OXIME

Chemical Property:

• PSA: 56.38000
• LogP: 1.36638

Purity/Quality:

97% ^*data from raw suppliers

3-CYANOBENZALDEHYDEOXIME 95 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-CYANOBENZALDEHYDE OXIME

There total 6 articles about 3-CYANOBENZALDEHYDE OXIME which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3-Cyanobenzaldehyde (24964-64-5) → 3-(hydroxyimino)methylbenzonitrile (64847-76-3)

Guidance literature:

With hydroxylamine hydrochloride; sodium hydroxide; In ethanol; water; at 25 ℃; for 1h; Cooling with ice;

Reference yield:

3-Cyanobenzaldehyde (24964-64-5) + hydroxylamine hydrochloride (5470-11-1) → 3-(hydroxyimino)methylbenzonitrile (64847-76-3)

Guidance literature:

With pyridine; In ethanol; at 20 ℃; for 12h;

Reference yield:

3-(hydroxymethyl)benzonitrile (874-97-5) → 3-(hydroxyimino)methylbenzonitrile (64847-76-3)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate; fluorosulfonyl fluoride; dimethyl sulfoxide / 12 h / 20 °C

2: hydroxylamine hydrochloride; potassium carbonate / 20 °C

With fluorosulfonyl fluoride; hydroxylamine hydrochloride; potassium carbonate; dimethyl sulfoxide;

DOI:10.1002/ejoc.201900478

upstream raw materials:

3-Cyanobenzaldehyde

3-(dichloromethyl)benzonitrile

3-Methylbenzonitrile

3-(chloromethyl)benzonitrile

Downstream raw materials:

benzene-1,3-dicarbonitrile

methyl 3-(3-cyanophenyl)-5-(methoxymethyl)isoxazoline-5-carboxylate

3-(3-cyano-phenyl)-5-methyl-4,5-dihydro-isoxazole-5-carboxylic acid methyl ester

3-(3-cyano-phenyl)-4,5-dihydro-isoxazole-5-carboxylic acid methyl ester

Refernces

• 1、 Calixto, Stephane Lima,Carvalho, Guilherme da Silva Louren?o,Coimbra, Elaine Soares,Granato, Juliana da Trindade,Louren?o, Maria Cristina da Silva,Wardell, James,da Costa, Cristiane Fran?a,de Souza, Marcus Vinicius Nora. "Synthesis and SAR study of simple aryl oximes and nitrofuranyl derivatives with potent activity against Mycobacterium tuberculosis". . p. 12 - 20. Retrieved 2020/02/06.
• 2、 Fang, Wan-Yin,Qin, Hua-Li. "Cascade Process for Direct Transformation of Aldehydes (RCHO) to Nitriles (RCN) Using Inorganic Reagents NH2OH/Na2CO3/SO2F2 in DMSO". . p. 5803 - 5812. Retrieved 2019/05/14.