(2-methylthiazol-5-yl)methanamine hydrochloride

Base Information

• Chemical Name: (2-methylthiazol-5-yl)methanamine hydrochloride
• CAS No.: 1072806-59-7
• Molecular Formula: C₅H₈N₂S*2ClH
• Molecular Weight: 201.12
• Mol file: 1072806-59-7.mol

Synonyms:(2-methylthiazol-5-yl)methanamine hydrochloride

Chemical Property of (2-methylthiazol-5-yl)methanamine hydrochloride

Chemical Property:

• PSA: 67.15000
• LogP: 2.41250

Purity/Quality:

99% ^*data from raw suppliers

(2-?Methyl-?1,?3-?thiazol-?5-?yl)?methanamineHydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: (2-?Methyl-?1,?3-?thiazol-?5-?yl)?methanamine Hydrochloride can be used as reactant/reagent in preparation of sulfonamidomethylpyridinecaboxamide derivs. and analogs for use as negative modulators of NR2A.

Technology Process of (2-methylthiazol-5-yl)methanamine hydrochloride

There total 3 articles about (2-methylthiazol-5-yl)methanamine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

(2-methyl-1,3-thiazol-5-yl)methanamine (63139-97-9) → (2-methylthiazol-5-yl)methanamine hydrochloride (1072806-59-7)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; dichloromethane; at 0 - 20 ℃; for 3h; Inert atmosphere;

Reference yield: 79.0%

5-(azidomethyl)-2-methylthiazole (1000686-12-3) → (2-methylthiazol-5-yl)methanamine dihydrochloride (1072806-59-7)

Guidance literature:

With hydrogenchloride; hydrogen; palladium 10% on activated carbon; In ethanol; water; for 18h;

Reference yield:

5-(hydroxymethyl)-2-methylthiazole (56012-38-5) → (2-methylthiazol-5-yl)methanamine dihydrochloride (1072806-59-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: methanesulfonyl chloride; triethylamine / tetrahydrofuran / 0.5 h / 0 °C

1.2: 18 h / 22 °C

2.1: hydrogenchloride; hydrogen / palladium 10% on activated carbon / ethanol; water / 18 h

With hydrogenchloride; hydrogen; methanesulfonyl chloride; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; ethanol; water;

upstream raw materials:

5-(azidomethyl)-2-methylthiazole

5-(hydroxymethyl)-2-methylthiazole

(2-methyl-1,3-thiazol-5-yl)methanamine

Refernces

• 1、 -. "HIV Integrase Inhibitors". Page/Page column 33. . Retrieved 2010/11/29.