(1R,2R)-ethyl 2-((R)-1-phenylethylaMino)cyclopentanecarboxylate hydrochloride

Base Information

• Chemical Name: (1R,2R)-ethyl 2-((R)-1-phenylethylaMino)cyclopentanecarboxylate hydrochloride
• CAS No.: 163877-11-0
• Molecular Formula: C16H24ClNO2
• Molecular Weight: 297.82026
• Mol file: 163877-11-0.mol

Synonyms:(1R,2R)-ethyl 2-((R)-1-phenylethylaMino)cyclopentanecarboxylate hydrochloride;(1R,2R)-ethyl 2-((R)-1-phenylethylaMino)cyclopentanecarboxylate

Chemical Property of (1R,2R)-ethyl 2-((R)-1-phenylethylaMino)cyclopentanecarboxylate hydrochloride

Chemical Property:

• PSA: 38.33000
• LogP: 4.26190
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%min ^*data from raw suppliers

(1R,2R)-Ethyl2-(((R)-1-phenylethyl)amino)cyclopentanecarboxylatehydrochloride 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (1R,2R)-ethyl 2-((R)-1-phenylethylaMino)cyclopentanecarboxylate hydrochloride

There total 3 articles about (1R,2R)-ethyl 2-((R)-1-phenylethylaMino)cyclopentanecarboxylate hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(S)-1-phenyl-ethylamine (2627-86-3) → (1R,2R)-2-((R)-1-Phenyl-ethylamino)-cyclopentanecarboxylic acid ethyl ester (163877-11-0)

Guidance literature:

Multi-step reaction with 2 steps

1: AcOH / ethanol

2: NaCNBH₃

With sodium cyanoborohydride; acetic acid; In ethanol;

DOI:10.1021/ja046280q

Reference yield:

2-ethoxycarbonyl-1-cyclopentanone (611-10-9) → (1R,2R)-2-((R)-1-Phenyl-ethylamino)-cyclopentanecarboxylic acid ethyl ester (163877-11-0)

Guidance literature:

Multi-step reaction with 2 steps

1: AcOH / ethanol

2: NaCNBH₃

With sodium cyanoborohydride; acetic acid; In ethanol;

DOI:10.1021/ja046280q

Reference yield:

2-[(E)-(R)-1-Phenyl-ethylimino]-cyclopentanecarboxylic acid ethyl ester → (1R,2R)-2-((R)-1-Phenyl-ethylamino)-cyclopentanecarboxylic acid ethyl ester (163877-11-0) + (1S,2S)-2-((R)-1-Phenyl-ethylamino)-cyclopentanecarboxylic acid ethyl ester

Guidance literature:

With sodium cyanoborohydride;

DOI:10.1021/ja046280q

upstream raw materials:

(S)-1-phenyl-ethylamine

2-ethoxycarbonyl-1-cyclopentanone

Downstream raw materials:

(1R,2R)-2-((tert-butoxycarbonyl)amino)cyclopentane-1-carboxylic acid

trans-(1R,2R)-2-aminocyclopentanecarboxylic acid

Refernces