Technology Process of 1,3,5(10)-ESTRATRIEN-3,11-ALPHA, 17-BETA-TRIOL 11-HEMISUCCINATE
There total 9 articles about 1,3,5(10)-ESTRATRIEN-3,11-ALPHA, 17-BETA-TRIOL 11-HEMISUCCINATE which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium tetrahydroborate;
In
methanol;
at 5 ℃;
for 0.0833333h;
DOI:10.1039/P19840002595
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 980 mg / 2,3-dichloro-5,6-dicyanobenzoquinone / methanol / 0.17 h / Ambient temperature
2: 860 mg / toluene-p-sulphonic acid / benzene / 2 h / Heating
3: 1.) diborane, 2.) 30percent aq. hydrogen peroxide, aq. sodium hydroxide / 1.) tetrahydrofuran, room temperature, 2 h, 2.) room temperature, overnight
4: 280 mg / toluene-p-sulphonic acid / methanol / 0.33 h / Heating
5: 4-dimethylaminopyridine / pyridine / 6 h / Heating
6: 230 mg / conc. hydrochloric acid / dioxane / 0.5 h / Heating
7: 180 mg / sodium borohydride / methanol / 0.08 h / 5 °C
With
hydrogenchloride; dmap; sodium hydroxide; sodium tetrahydroborate; dihydrogen peroxide; toluene-4-sulfonic acid; 2,3-dicyano-5,6-dichloro-p-benzoquinone; diborane;
In
1,4-dioxane; pyridine; methanol; benzene;
DOI:10.1039/P19840002595
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 860 mg / toluene-p-sulphonic acid / benzene / 2 h / Heating
2: 1.) diborane, 2.) 30percent aq. hydrogen peroxide, aq. sodium hydroxide / 1.) tetrahydrofuran, room temperature, 2 h, 2.) room temperature, overnight
3: 280 mg / toluene-p-sulphonic acid / methanol / 0.33 h / Heating
4: 4-dimethylaminopyridine / pyridine / 6 h / Heating
5: 230 mg / conc. hydrochloric acid / dioxane / 0.5 h / Heating
6: 180 mg / sodium borohydride / methanol / 0.08 h / 5 °C
With
hydrogenchloride; dmap; sodium hydroxide; sodium tetrahydroborate; dihydrogen peroxide; toluene-4-sulfonic acid; diborane;
In
1,4-dioxane; pyridine; methanol; benzene;
DOI:10.1039/P19840002595
