1-(5-aMino-1,3-dihydro-2H-isoindol-2-yl)-Ethanone

Base Information

• Chemical Name: 1-(5-aMino-1,3-dihydro-2H-isoindol-2-yl)-Ethanone
• CAS No.: 722444-62-4
• Molecular Formula: C10H12N2O
• Molecular Weight: 176.21508
• Mol file: 722444-62-4.mol

Synonyms:1-(5-aMino-1,3-dihydro-2H-isoindol-2-yl)-Ethanone

Chemical Property of 1-(5-aMino-1,3-dihydro-2H-isoindol-2-yl)-Ethanone

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

1-(5-amino-2,3-dihydro-1H-isoindol-2-yl)ethan-1-one ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(5-aMino-1,3-dihydro-2H-isoindol-2-yl)-Ethanone

There total 3 articles about 1-(5-aMino-1,3-dihydro-2H-isoindol-2-yl)-Ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

C10H10N2O3 → C10H12N2O (722444-62-4)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 15 ℃; for 18h; under 775.743 Torr;

Reference yield:

isoindoline (496-12-8) → C10H12N2O (722444-62-4)

Guidance literature:

Multi-step reaction with 3 steps

1: nitric acid; sulfuric acid / dichloromethane; water / 0.5 h / -20 - 20 °C / Inert atmosphere

2: triethylamine / dichloromethane / 2 h / 0 - 20 °C

3: hydrogen; palladium 10% on activated carbon / methanol / 18 h / 15 °C / 775.74 Torr

With sulfuric acid; palladium 10% on activated carbon; hydrogen; nitric acid; triethylamine; In methanol; dichloromethane; water;

Reference yield:

5-nitroisoindoline (46053-72-9) → C10H12N2O (722444-62-4)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 2 h / 0 - 20 °C

2: hydrogen; palladium 10% on activated carbon / methanol / 18 h / 15 °C / 775.74 Torr

With palladium 10% on activated carbon; hydrogen; triethylamine; In methanol; dichloromethane;

upstream raw materials:

isoindoline

5-nitroisoindoline

Refernces