2-(4-ethyl-3-iodophenyl)-2-Methylpropanoic acid

Base Information

• Chemical Name: 2-(4-ethyl-3-iodophenyl)-2-Methylpropanoic acid
• CAS No.: 1256584-73-2
• Molecular Formula: C₁₂H₁₅IO₂
• Molecular Weight: 318.154
• Mol file: 1256584-73-2.mol

Synonyms:2-(4-ethyl-3-iodophenyl)-2-Methylpropanoic acid;2-(4-ethyl-3-iodophenyl)-2-Methylpropanoic acid-7

Chemical Property of 2-(4-ethyl-3-iodophenyl)-2-Methylpropanoic acid

Chemical Property:

• Boiling Point: 369.6±27.0 °C(Predicted)
• PKA: 4.32±0.11(Predicted)
• PSA: 37.30000
• Density: 1.547±0.06 g/cm3(Predicted)
• LogP: 3.21580

Purity/Quality:

99.9% ^*data from raw suppliers

2-?(4-?Ethyl-?3-?iodophenyl)?-?2-?methylpropanoicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-?(4-?Ethyl-?3-?iodophenyl)?-?2-?methylpropanoic Acid is an intermediate of Alectinib (C183360), a highly selective and potent anaplastic lymphoma kinase (ALK) inhibitor capable of blocking the resistant gatekeeper mutant, which results in reduced cell growth.

Technology Process of 2-(4-ethyl-3-iodophenyl)-2-Methylpropanoic acid

There total 17 articles about 2-(4-ethyl-3-iodophenyl)-2-Methylpropanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methyl 2-(4-ethyl-3-iodophenyl)-2-methyl-propionate → 2-(4-ethyl-3-iodophenyl)-2-methylpropanoic acid (1256584-73-2)

Guidance literature:

With water; sodium hydroxide; at 20 ℃; for 3h;

Reference yield: 90.0%

2-(4-ethylphenyl)-2-methyl-propanoic acid (1247119-83-0) → 2-(4-ethyl-3-iodophenyl)-2-methylpropanoic acid (1256584-73-2)

Guidance literature:

With N-iodo-succinimide; sulfuric acid; acetic acid; at 0 - 30 ℃;

Reference yield: 90.0%

2-(4-acetyl-phenyl)-2-methyl-propionic acid (857768-18-4) → 2-(4-ethyl-3-iodophenyl)-2-methylpropanoic acid (1256584-73-2)

Guidance literature:

With N-iodo-succinimide; sulfuric acid; In acetic acid; at 0 - 20 ℃; for 2h;

upstream raw materials:

2-(4-ethylphenyl)-2-methyl-propanoic acid

ethylbenzene

2-bromo-1-(4-ethylphenyl)-2-methyl-propan-1-one

methyl 2-(4-ethylphenyl)-2-methyl-propanoate

Downstream raw materials:

C⁽²⁴⁸⁾H₅₄₀₂

Refernces

• 1、 -. "Preparation method and intermediate of halogenated aromatic hydrocarbon compound". Paragraph 0145-0147. . Retrieved 2020/07/14.
• 2、 -. "Preparation method of aromatic hydrocarbon compound". . . Retrieved 2020/12/30.