(R)-benzyl piperidin-3-ylmethylcarbamate

Base Information

• Chemical Name: (R)-benzyl piperidin-3-ylmethylcarbamate
• CAS No.: 683269-48-9
• Molecular Formula: C14H20N2O2
• Molecular Weight: 248.3208
• Hs Code.: 2933399090
• Mol file: 683269-48-9.mol

Synonyms:(R)-benzyl piperidin-3-ylmethylcarbamate;benzyl N-[(3R)-piperidin-3-ylMethyl]carbaMate;N-[(3R)-3-piperidinylmethyl]carbamic acid phenylmethyl ester;Phenylmethyl [(3R)-3-piperidinylmethyl]carbamate;R-3-N-Cbz-aminomethyl piperidine

Chemical Property of (R)-benzyl piperidin-3-ylmethylcarbamate

Chemical Property:

• PSA: 50.36000
• Density: 1.081
• LogP: 2.63210

Purity/Quality:

97% ^*data from raw suppliers

R-3-N-CBZ-AMINOMETHYL PIPERIDINE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (R)-benzyl piperidin-3-ylmethylcarbamate

There total 4 articles about (R)-benzyl piperidin-3-ylmethylcarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl (3R)-3-(hydroxymethyl)piperidine-1-carboxylate (116574-71-1,140645-19-8,140695-84-7,140695-85-8) → (R)-3-[(benzyloxycarbonylamino)methyl]-piperidine (683269-48-9)

Guidance literature:

Multi-step reaction with 5 steps

1: 98 percent / NEt₃ / CH₂Cl₂ / 1.5 h / 0 °C

2: 98 percent / sodium azide / dimethylformamide / 24 h / 50 °C

3: 98 percent / H₂ / Pd/C / ethanol / 1.5 h / 7500.6 Torr / Ambient temperature

4: 100 percent / tetrabutylammonium hydrogen sulfate, aq. 1 N NaOH / hexane / 3 h / Ambient temperature

5: 4 M aq. HCl / ethyl acetate / 4 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; sodium azide; hydrogen; tetra(n-butyl)ammonium hydrogensulfate; triethylamine; palladium on activated charcoal; In ethanol; hexane; dichloromethane; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1021/jm00049a008

Reference yield:

(R)-3-(azidomethyl)piperidine-1-carboxylic acid tert-butyl ester (155541-67-6) → (R)-3-[(benzyloxycarbonylamino)methyl]-piperidine (683269-48-9)

Guidance literature:

Multi-step reaction with 3 steps

1: 98 percent / H₂ / Pd/C / ethanol / 1.5 h / 7500.6 Torr / Ambient temperature

2: 100 percent / tetrabutylammonium hydrogen sulfate, aq. 1 N NaOH / hexane / 3 h / Ambient temperature

3: 4 M aq. HCl / ethyl acetate / 4 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; hydrogen; tetra(n-butyl)ammonium hydrogensulfate; palladium on activated charcoal; In ethanol; hexane; ethyl acetate;

DOI:10.1021/jm00049a008

Reference yield:

(R)-<<(methylsulfonyl)oxy>methyl>piperidine-1-carboxylic acid tert-butyl ester (161285-05-8) → (R)-3-[(benzyloxycarbonylamino)methyl]-piperidine (683269-48-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 98 percent / sodium azide / dimethylformamide / 24 h / 50 °C

2: 98 percent / H₂ / Pd/C / ethanol / 1.5 h / 7500.6 Torr / Ambient temperature

3: 100 percent / tetrabutylammonium hydrogen sulfate, aq. 1 N NaOH / hexane / 3 h / Ambient temperature

4: 4 M aq. HCl / ethyl acetate / 4 h / Ambient temperature

With hydrogenchloride; sodium hydroxide; sodium azide; hydrogen; tetra(n-butyl)ammonium hydrogensulfate; palladium on activated charcoal; In ethanol; hexane; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1021/jm00049a008

upstream raw materials:

tert-butyl (3R)-3-(hydroxymethyl)piperidine-1-carboxylate

tert-butyl (3S)-3-(aminomethyl)piperidine-1-carboxylate

(R)-3-(azidomethyl)piperidine-1-carboxylic acid tert-butyl ester

(R)-<<(methylsulfonyl)oxy>methyl>piperidine-1-carboxylic acid tert-butyl ester

Refernces