2，2-dichloro-1-(4-ethyoxy phenyl)cy-clopropane carboxylic acid

Base Information

• Chemical Name: 2，2-dichloro-1-(4-ethyoxy phenyl)cy-clopropane carboxylic acid
• CAS No.: 63935-26-2
• Molecular Weight: 0
• Mol file: 63935-26-2.mol

Synonyms:2，2-dichloro-1-(4-ethyoxy phenyl)cy-clopropane carboxylic acid

Chemical Property of 2，2-dichloro-1-(4-ethyoxy phenyl)cy-clopropane carboxylic acid

Chemical Property:

Purity/Quality:

98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2，2-dichloro-1-(4-ethyoxy phenyl)cy-clopropane carboxylic acid

There total 16 articles about 2，2-dichloro-1-(4-ethyoxy phenyl)cy-clopropane carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(1R)-[(R)-2'-methoxy-1,1'-binaphth-2-yl] 1-(4-ethoxyphenyl)-2,2-dichlorocyclopropanecarboxylate → (-)-(R)-2,2-dichloro-1-(4-ethoxyphenyl)cyclopropanecarboxylic acid (63935-26-2)

Guidance literature:

With potassium hydroxide; In tetrahydrofuran; water; at 60 - 65 ℃; for 7h;

DOI:10.1039/b714614k

Reference yield: 95.0%

1-(4-ethoxyphenyl)-2,2-dichlorocyclopropane-1-carboxylic acid methyl ester (101492-41-5,928118-58-5) → 1-(4'-ethoxyphenyl)-2,2-dichlorocyclopropane-1-carboxylic acid (104023-75-8,63935-26-2)

Guidance literature:

With sodium hydroxide; In methanol; for 3h; Heating;

DOI:10.1002/adsc.200505450

Reference yield: 94.0%

(1S)-[(R)-2'-methoxy-1,1'-binaphth-2-yl] 1-(4-ethoxyphenyl)-2,2-dichlorocyclopropanecarboxylate → (+)-(S)-2,2-dichloro-1-(4-ethoxyphenyl)cyclopropanecarboxylic acid (63935-60-4,63935-26-2)

Guidance literature:

With potassium hydroxide; In tetrahydrofuran; water; at 60 - 65 ℃; for 7h;

DOI:10.1039/b714614k

upstream raw materials:

1-(4-ethoxyphenyl)-2,2-dichlorocyclopropane-1-carboxylic acid methyl ester

2-(4-ethoxy-phenyl)-acrylic acid methyl ester

methyl 2-(4-ethoxyphenyl)lactate

Phenetole

Downstream raw materials:

2,2-dichloro-1-(4-ethoxyphenyl)-N-(4-nitrophenyl)-cyclopropane carboxamide

Refernces

• 1、 Si, Yu-Gui,Chen, Jun,Li, Fan,Li, Jin-Hua,Qin, Ye-Jun,Jiang, Biao. "Highly regioselective Friedel-Crafts reactions of electron-rich aromatic compounds with pyruvate catalyzed by Lewis acid-base: Efficient synthesis of pesticide cycloprothrin". . p. 898 - 904. Retrieved 2007/10/03.
• 2、 -. "2,3-Isopropylidene ribonic acid, 1,4-lactones". . . Retrieved 2008/06/13.