2,2-di-but-3-enyl-malonic acid diethyl ester

Base Information

• Chemical Name: 2,2-di-but-3-enyl-malonic acid diethyl ester
• CAS No.: 51481-48-2
• Molecular Weight: 268.353
• Mol file: 51481-48-2.mol

Synonyms:2,2-di-but-3-enyl-malonic acid diethyl ester

Chemical Property of 2,2-di-but-3-enyl-malonic acid diethyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,2-di-but-3-enyl-malonic acid diethyl ester

There total 1 articles about 2,2-di-but-3-enyl-malonic acid diethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

1-bromo-4-butene (5162-44-7) + diethyl malonate (105-53-3) → diethyl 2-(3-butenyl)malonate (31696-00-1) + 2,2-di-but-3-enyl-malonic acid diethyl ester (51481-48-2)

Guidance literature:

diethyl malonate; With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃; for 1h; Inert atmosphere;

1-bromo-4-butene; at 20 ℃; for 12h;

DOI:10.1055/s-0032-1317020

Reference yield: 89.0%

2,2-di-but-3-enyl-malonic acid diethyl ester (51481-48-2) → diethyl cycloheptane-1,1-dicarboxylate (6557-83-1)

Guidance literature:

2,2-di-but-3-enyl-malonic acid diethyl ester; With dichloro(3-phenyl-1H-inden-1-ylidene)bis(tricyclohexylphosphine)ruthenium(II); In tetrahydrofuran; at 40 ℃; for 0.5h; Inert atmosphere;

With formic acid; sodium hydride; In tetrahydrofuran; at 80 ℃; for 6h; Inert atmosphere;

DOI:10.1021/acs.joc.7b02468

Reference yield:

2,2-di-but-3-enyl-malonic acid diethyl ester (51481-48-2) → ethene (74-85-1) + cyclohex-3-ene-1,1-dicarboxylic acid diethyl ester (38511-09-0)

Guidance literature:

With Hoveyda-Grubbs catalyst second generation; In ⁽²⁾H₈-toluene; at 29.84 ℃; Reagent/catalyst;

DOI:10.1002/chem.201204150

upstream raw materials:

1-bromo-4-butene

diethyl malonate

Downstream raw materials:

ethene

cyclohex-3-ene-1,1-dicarboxylic acid diethyl ester

diethyl cycloheptane-1,1-dicarboxylate

(4S,4'S)-2,2'-(cycloheptane-1,1-diyl)bis(4-phenyl-4,5-dihydrooxazole)

Refernces

• 1、 Kotha, Sambasivarao,Shirbhate, Mukesh E.. "A general synthetic approach to para-cyclophanes via ring-closing metathesis". . p. 1483 - 1494. Retrieved 2016/09/09.