Ditert-butyl 1,4-Benzyldicarbamate

Base Information

• Chemical Name: Ditert-butyl 1,4-Benzyldicarbamate
• CAS No.: 20580-52-3
• Molecular Formula: C18H28N2O4
• Molecular Weight: 336.431
• Mol file: 20580-52-3.mol

Synonyms:Ditert-butyl 1,4-Benzyldicarbamate

Chemical Property of Ditert-butyl 1,4-Benzyldicarbamate

Chemical Property:

• PSA: 76.66000
• LogP: 4.51780

Purity/Quality:

99%min. ^*data from raw suppliers

Ditert-butyl 1,4-Benzyldicarbamate 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ditert-butyl 1,4-Benzyldicarbamate

There total 4 articles about Ditert-butyl 1,4-Benzyldicarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

di-tert-butyl dicarbonate (24424-99-5) + p-xylylidenediamine (539-48-0) → N,N'-di-Boc-p-xylylenediamine (20580-52-3)

Guidance literature:

With triethylamine; In dichloromethane; at 20 ℃; Product distribution / selectivity;

Reference yield: 90.0%

di-tert-butyl dicarbonate (24424-99-5) + 1,4-bis(aminomethyl)benzene dihydrochloride (51964-30-8,3057-45-2,116599-23-6) → N,N'-di-Boc-p-xylylenediamine (20580-52-3)

Guidance literature:

1,4-bis(aminomethyl)benzene dihydrochloride; With triethylamine; at 20 ℃;

di-tert-butyl dicarbonate; at 20 ℃; Inert atmosphere;

DOI:10.1002/chem.201103434

Reference yield: 42.0%

di-tert-butyl dicarbonate (24424-99-5) + p-xylylidenediamine (539-48-0) → N,N'-di-Boc-p-xylylenediamine (20580-52-3) + tert-butyl 4-(aminomethyl)benzylcarbamate (108468-00-4)

Guidance literature:

With sodium hydroxide; In 1,4-dioxane; water; at 20 ℃; Cooling with ice;

DOI:10.1016/j.bmc.2011.03.045

upstream raw materials:

di-tert-butyl dicarbonate

p-xylylidenediamine

1,4-bis(aminomethyl)benzene dihydrochloride

Downstream raw materials:

N,N'-dipropargyl-N,N'-di-Boc-p-xylylenediamine

N,N'-dibutyl-N,N'-di-Boc-p-xylylenediamine

N,N'-dipropyl-p-xylylenediammonium chloride

N,N'-dibenzyl-p-xylylenediammonium chloride

Refernces

• 1、 Keller, Max,Erdmann, Daniela,Pop, Nathalie,Pluym, Nikola,Teng, Shangjun,Bernhardt, Günther,Buschauer, Armin. "Red-fluorescent argininamide-type NPY Y1 receptor antagonists as pharmacological tools". experimental part. p. 2859 - 2878. Retrieved 2011/06/22.