3-Phthalimidopropionaldehyde

Base Information

• Chemical Name: 3-Phthalimidopropionaldehyde
• CAS No.: 2436-29-5
• Molecular Formula: C11H9NO3
• Molecular Weight: 203.197
• Hs Code.: 2925190090
• European Community (EC) Number: 700-133-0
• NSC Number: 166600
• DSSTox Substance ID: DTXSID90179097
• Nikkaji Number: J50.517J
• Mol file: 2436-29-5.mol

Synonyms:2436-29-5;3-(1,3-Dioxoisoindolin-2-yl)propanal;3-Phthalimidopropionaldehyde;3-(1,3-dioxoisoindol-2-yl)propanal;3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-propionaldehyde;Phthalimide, N-(2-formylethyl)-;2H-Isoindole-2-propanal, 1,3-dihydro-1,3-dioxo-;3-(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)propanal;beta-Phthalimidopropionaldehyde;NSC 166600;BRN 0165375;3-(1,3-dioxo-1,3-dihydroisoindol-2-yl)propionaldehyde;EC 700-133-0;5-21-10-00396 (Beilstein Handbook Reference);3-(1,3-DIOXO-1,3-DIHYDroisoINDOL-2-yl)propaNALDEHYDE;3-Phthalimidylpropanal;n-(2-formylethyl)phthalimide;NSC166600;3-Phthalimidopropanal;3-phthalimidopropanaldehyde;3-phthalimidopropionic aldehyde;SCHEMBL1042197;WLN: T56 BVNVJ C2VH;.beta.-Phthalimidopropionaldehyde;DTXSID90179097;AB9155;MFCD01704466;2-(3-Oxopropyl)isoindole-1,3-dione;AKOS012339440;NSC-166600;SB36139;AS-44947;LS-109472;FT-0654488;EN300-226117;2H-Isoindole-2-propanal,3-dihydro-1,3-dioxo-;1,3-Dihydro-1,3-dioxo-2H-isoindole-2-propanal;A817246;3-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)propanal;Z1080365456;3-(1,3-dioxo-1,3-dihydro-isoindol-2-yl)-propionaldehyde, AldrichCPR

Chemical Property of 3-Phthalimidopropionaldehyde

Chemical Property:

• Appearance/Colour: white solid
• Vapor Pressure: 3.77E-05mmHg at 25°C
• Melting Point: 136-141 °C
• Refractive Index: 1.587
• Boiling Point: 352.7 °C at 760 mmHg
• PKA: -2.24±0.20(Predicted)
• Flash Point: 165 °C
• PSA: 54.45000
• Density: 1.319 g/cm³
• LogP: 0.80950
• Storage Temp.: Inert atmosphere,Store in freezer, under -20°C
• XLogP3: 0.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 203.058243149
• Heavy Atom Count: 15
• Complexity: 276

Purity/Quality:

99% , ^*data from raw suppliers

3-(1,3-Dioxoisoindolin-2-yl)propanal ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 22-36-43
• Safety Statements: 26-36/37

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C(=O)N(C2=O)CCC=O

Technology Process of 3-Phthalimidopropionaldehyde

There total 47 articles about 3-Phthalimidopropionaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

phthalimide (136918-14-4,85-41-6) + acrolein (107-02-8,25068-14-8) → 3-(N-phthaloyl)propionaldehyde (2436-29-5)

Guidance literature:

With N-benzyl-trimethylammonium hydroxide; In methanol; ethyl acetate; at 65 ℃; for 0.333333h;

DOI:10.1002/anie.201703109

Reference yield: 100.0%

N-(3-hydroxypropyl)phthalimide (883-44-3) → 3-(N-phthaloyl)propionaldehyde (2436-29-5)

Guidance literature:

With 2-iodoxybenzoic acid; In ethyl acetate; for 2h; Reflux;

Reference yield: 100.0%

2(S)-benzyloxycarbonylamino-3-[2-[3-(2-(N-imidazolin-2-yl)-aminoethyl)isoxazolin-5-(R,S)-yl]ethylcarbonylamino]propionic acid + N-(2-[1,3]dioxolan-2-yl-ethyl)-phthalimide (185563-61-5) → 3-(N-phthaloyl)propionaldehyde (2436-29-5)

Guidance literature:

With hydrogenchloride; In 1,4-dioxane; water;

upstream raw materials:

phthalic anhydride

potassium phtalimide

N-vinylphthalimide

carbon monoxide

Downstream raw materials:

N-<2-(4,5,6,7-Tetrahydro-2-benzimidazolyl)-ethyl>-phthalamid

2-(3-((((3aR,4R,6R,6aR)-6-(6-amino-9H-purin-9-yl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)methyl)amino)propyl)isoindoline-1,3-dione

Refernces

• 1、 Domeyer, Svenja,Bjerregaard, Mark,Johansson, Henrik,Pedersen, Daniel Sejer. "Exploring endoperoxides as a new entry for the synthesis of branched azasugars". . p. 644 - 647. Retrieved 2017.
• 2、 Moe,Warner. "-". . p. 1251. Retrieved 1949.
• 3、 Huang, Huan-Ming,Bellotti, Peter,Erchinger, Johannes E.,Paulisch, Tiffany O.,Glorius, Frank. "Radical Carbonyl Umpolung Arylation via Dual Nickel Catalysis". supporting information. p. 1899 - 1909. Retrieved 2022/02/01.
• 4、 Nagib, David A.,Rafferty, Sean M.,Rutherford, Joy E.,Wang, Lu,Zhang, Lumin. "Cross-Selective Aza-Pinacol Coupling via Atom Transfer Catalysis". supporting information. p. 5622 - 5628. Retrieved 2021/05/07.