5-Methyl-3-thiophenemethanol

Base Information

• Chemical Name: 5-Methyl-3-thiophenemethanol
• CAS No.: 207277-11-0
• Molecular Weight: 128.19
• European Community (EC) Number: 967-902-2
• Nikkaji Number: J948.369A
• Mol file: 207277-11-0.mol

Synonyms:(5-methylthiophen-3-yl)methanol;207277-11-0;5-methyl-3-thiophenemethanol;(5-methyl-3-thienyl)methanol;SCHEMBL2735670;TZUNKFFVTXJZRN-UHFFFAOYSA-N;AKOS001921285;AT16765;CS-0214912;(5-Methylthiophen-3-yl)methanol, AldrichCPR;EN300-204178

Chemical Property of 5-Methyl-3-thiophenemethanol

Chemical Property:

• XLogP3: 1.1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 128.02958605
• Heavy Atom Count: 8
• Complexity: 74.9

Purity/Quality:

99% ^*data from raw suppliers

(5-Methylthiophen-3-yl)methanol 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1=CC(=CS1)CO

Technology Process of 5-Methyl-3-thiophenemethanol

There total 5 articles about 5-Methyl-3-thiophenemethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-methyl-4-thiophenecarboxaldehyde (29421-72-5) → (5-methylthiophen-3-yl)methanol (207277-11-0)

Guidance literature:

With [Ir(2,2':6',2'’-terpyridine)(1,10-phenanthroline)Cl](PF₆)₂; sodium formate; In ethanol; water; at 100 ℃; for 0.75h; chemoselective reaction; Microwave irradiation;

DOI:10.1016/j.jcat.2019.08.025

Reference yield:

5-methyl-thiophene-3-carboxylic acid (19156-50-4) → (5-methylthiophen-3-yl)methanol (207277-11-0)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 20 ℃; for 2h;

Reference yield:

tert-butyl(dimethyl)(3-thienylmethoxy)silane (117657-52-0) + methyl iodide (74-88-4) → (2-methyl-3-thienyl)methanol (857979-28-3) + (5-methylthiophen-3-yl)methanol (207277-11-0)

Guidance literature:

tert-butyl(dimethyl)(3-thienylmethoxy)silane; With sec.-butyllithium; In tetrahydrofuran; hexane; cyclohexane; at -78 ℃; for 0.5h;

methyl iodide; In tetrahydrofuran; hexane; cyclohexane; at -78 ℃; for 1h;

upstream raw materials:

3-hydroxymethyl-thiophene

methyl iodide

tert-butyl(dimethyl)(3-thienylmethoxy)silane

5-methyl-thiophene-3-carboxylic acid

Downstream raw materials:

2-methyl-4-thiophenecarboxaldehyde

Refernces

• 1、 -. "MACROCYCLES AS PDE1 INHIBITORS". Paragraph 0207; 0208. . Retrieved 2019/06/30.
• 2、 -. "COMBINATION TREATMENTS COMPRISING ADMINISTRATION OF 1H-PYRAZOLO[4,3-B]PYRIDINES". Page/Page column 101. . Retrieved 2019/07/19.