Clobetasone

Base Information

• Chemical Name: Clobetasone
• CAS No.: 54063-32-0
• Molecular Formula: C₂₂H₂₆ClFO₄
• Molecular Weight: 408.897
• European Community (EC) Number: 258-953-5
• UNII: LT69WY1J6D
• DSSTox Substance ID: DTXSID601023875
• Nikkaji Number: J12.437K
• Wikipedia: Clobetasone
• Wikidata: Q5134764
• NCI Thesaurus Code: C77408
• Metabolomics Workbench ID: 154011
• Mol file: 54063-32-0.mol

Synonyms:Clobetasone;54063-32-0;Clobetasona;Clobetasonum;(8S,9R,10S,13S,14S,16S,17R)-17-(2-chloroacetyl)-9-fluoro-17-hydroxy-10,13,16-trimethyl-7,8,12,14,15,16-hexahydro-6H-cyclopenta[a]phenanthrene-3,11-dione;Clobetasone [INN:BAN];Clobetasonum [INN-Latin];UNII-LT69WY1J6D;Clobetasona [INN-Spanish];LT69WY1J6D;Clobetasone (INN);EINECS 258-953-5;CLOBETASONE [INN];21-Chlor-9-fluor-17-hydroxy-16beta-methyl-1,4-pregnadien-3,11,20-trion;21-Chloro-11-dehydrobetamethasone;CLOBETASONE [MI];SCHEMBL3581;C22H26ClFO4;CLOBETASONE [WHO-DD];GTPL9088;C22-H26-Cl-F-O4;CHEBI:177795;Pregna-1,4-diene-3,11,20-trione, 21-chloro-9-fluoro-17-hydroxy-16-methyl-, (16.beta.)-;DTXSID601023875;DB13158;D07717;A903652;EN300-19844879;Q5134764;CLOBETASONE BUTYRATE IMPURITY A [EP IMPURITY];(16-beta)-21-Chloro-9-fluoro-17-hydroxy-16-methylpregna-1,4-diene-3,11,20-trione;21-CHLORO-9-FLUORO-17-HYDROXY-16.BETA.-METHYLPREGNA-1,4-DIENE-3,11,20-TRIONE;21-chloro-9alpha-fluoro-17alpha-hydroxy-16beta-methylpregna-1,4-diene-3,11,20-trione;(1R,2S,3aS,3bS,9aS,9bR,11aS)-1-(2-chloroacetyl)-9b-fluoro-1-hydroxy-2,9a,11a-trimethyl-1H,2H,3H,3aH,3bH,4H,5H,7H,9aH,9bH,10H,11H,11aH-cyclopenta[a]phenanthrene-7,10-dione;(8S,9R,10S,13S,14S,16S,17R)-17-(2-chloroacetyl)-9-luoro-17-hydroxy-10,13,16-trimethyl-7,8,12,14,15,16-hexahydro-6H-cyclopenta[a]phenanthrene-3,11-dione;PREGNA-1,4-DIENE-3,11,20-TRIONE, 21-CHLORO-9-FLUORO-16-METHYL-17-HYDROXY-, (16.BETA.)-

Chemical Property of Clobetasone

Chemical Property:

• Vapor Pressure: 2.42E-14mmHg at 25°C
• Boiling Point: 549°Cat760mmHg
• Flash Point: 285.8°C
• PSA: 71.44000
• Density: 1.32g/cm³
• LogP: 3.35040
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 2
• Exact Mass: 408.1503652
• Heavy Atom Count: 28
• Complexity: 850

Purity/Quality:

HPLC≥98% ^*data from raw suppliers

CLOBETASONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1CC2C3CCC4=CC(=O)C=CC4(C3(C(=O)CC2(C1(C(=O)CCl)O)C)F)C
• Isomeric SMILES: C[C@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@@]4([C@]3(C(=O)C[C@@]2([C@]1(C(=O)CCl)O)C)F)C
• Uses: Anti-inflammatory. Clobetasone is an impurity of Clobetasone 17-Butyrate (C583550).

Technology Process of Clobetasone

There total 1 articles about Clobetasone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ clobetasone (54063-32-0)

Guidance literature:

Refernces