Levonordefrin

Base Information

• Chemical Name: Levonordefrin
• CAS No.: 829-74-3
• Deprecated CAS: 13725-11-6,16906-83-5,34535-70-1
• Molecular Formula: C9H13NO3
• Molecular Weight: 183.207
• Hs Code.: 2922504500
• NSC Number: 757084
• UNII: V008L6478D,R81X549E70
• DSSTox Substance ID: DTXSID6046349
• Nikkaji Number: J7.129C
• Wikipedia: Corbadrine
• Wikidata: Q12745763
• NCI Thesaurus Code: C47584,C81340
• RXCUI: 132889
• Pharos Ligand ID: KWPP6JDBMBBS
• Metabolomics Workbench ID: 43687
• ChEMBL ID: CHEMBL677
• Mol file: 829-74-3.mol

Synonyms:3,4 Dihydroxynorephedrine;3,4-Dihydroxynorephedrine;4-(2-Amino-1-hydroxypropyl)-1,2-benzenediol;4-(2-Amino-1-hydroxypropyl)-1,2-benzenediol Hydrochloride, (R*,R*)-(+,-)-Isomer;4-(2-Amino-1-hydroxypropyl)-1,2-benzenediol Hydrochloride, (R*,S*)-(+-)-Isomer;4-(2-Amino-1-hydroxypropyl)-1,2-benzenediol Tartrate, (R*,R*), (R*,R*)-Isomer;4-(2-Amino-1-hydroxypropyl)-1,2-benzenediol Tartrate, (R*,S*), (R*,R*)-Isomer;4-(2-Amino-1-hydroxypropyl)-1,2-benzenediol, (R*,R*)-Isomer;4-(2-Amino-1-hydroxypropyl)-1,2-benzenediol, (R*,S*)-Isomer;alpha Methylnoradrenaline;alpha Methylnorepinephrine;alpha-Methylnoradrenaline;alpha-Methylnorepinephrine;Cobefrine;Corbadrine;Hydrochloride, Nordefrin;Levonordefrin;Methylnorepinephrine;Neo Cobefrin;Neo-Cobefrin;NeoCobefrin;Nordefrin;Nordefrin Hydrochloride;Nordefrin Hydrochloride, (R*,R*)-(+,-)-Isomer;Nordefrin Hydrochloride, (R*,S*)-(+,-)-Isomer;Nordefrin Tartrate, (R*,R*), (R*,R*) Isomer;Nordefrin Tartrate, (R*,S*), (R*,R*) Isomer;Nordefrin, (R*,R*)-Isomer;Nordefrin, (R*,S*)-Isomer;Norephrine

 This product is a nationally controlled contraband, and the Lookchem platform doesn't provide relevant sales information.

Chemical Property of Levonordefrin

Chemical Property:

• Appearance/Colour: white powder
• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 212-215 °C
• Refractive Index: 1.633
• Boiling Point: 654.8 °C at 760 mmHg
• PKA: 9.59±0.10(Predicted)
• Flash Point: 349.8 °C
• PSA: 86.71000
• Density: 1.328g/cm³
• LogP: 1.17870
• Storage Temp.: −20°C
• Solubility.: DMSO: soluble5mg/mL, clear (warmed)
• XLogP3: -0.8
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 2
• Exact Mass: 183.08954328
• Heavy Atom Count: 13
• Complexity: 165

Purity/Quality:

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC(C(C1=CC(=C(C=C1)O)O)O)N
• Isomeric SMILES: C[C@@H]([C@@H](C1=CC(=C(C=C1)O)O)O)N
• Uses: A vasoconstrictor which also increases the potency and duration of anesthesia produced by local anesthetics Vasoconstrictor;Adrenergic receptor agonist

Technology Process of Levonordefrin

There total 3 articles about Levonordefrin which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ threo-2-amino-1-(3.4-dihydroxy-phenyl)-propanol-(1) (829-74-3,829-75-4,6539-57-7,16202-33-8,16906-82-4,20521-15-7,20727-99-5,74812-63-8,18829-78-2)

Guidance literature:

With methanol; palladium on activated charcoal; Hydrogenation;

Reference yield:

(S)-2-methoxy-2-phenylacetic acid (26164-26-1) → levonordefrin (829-74-3,18829-78-2)

Guidance literature:

With water; platinum; Hydrogenation;

Reference yield:

→ levonordefrin (829-74-3,18829-78-2)

Guidance literature:

aus den Loesungen der Salze in Methanol scheidet sich das d-weinsaure Salz der linksdrehenden Form bzw.das l-weinsaure Salz der rechtsdrehenden Form zuerst ab;

upstream raw materials:

(S)-2-methoxy-2-phenylacetic acid