(R)-N-FMOC-alpha-Methylvaline, 98% ee, 98%

Base Information

• Chemical Name: (R)-N-FMOC-alpha-Methylvaline, 98% ee, 98%
• CAS No.: 616867-28-8
• Molecular Formula: C21H23NO4
• Molecular Weight: 353.418
• Mol file: 616867-28-8.mol

Synonyms:(R)-N-FMOC-alpha-Methylvaline, 98% ee, 98%;(R)-N-FMOC-alpha-Methylvaline, 98%, 98% ee;FMoc-(R)-2-aMino-2,3-diMethylbutanoic acid;(R)-N-FMOC-alpha-Methylvaline;FMoc-α-Me-D-Val-OH;Fmoc-α-methyl-D-Valine;(R)-N-Fmoc-a-Methylvaline;Fmoc-alpha-Me-D-Val-OH

Chemical Property of (R)-N-FMOC-alpha-Methylvaline, 98% ee, 98%

Chemical Property:

• Vapor Pressure: 4.12E-13mmHg at 25°C
• Boiling Point: 554.1°C at 760 mmHg
• PKA: 4.02±0.16(Predicted)
• Flash Point: 288.9°C
• PSA: 75.63000
• Density: 1.209g/cm³
• LogP: 4.41530
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C

Purity/Quality:

98%Min ^*data from raw suppliers

(R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-2,3-dimethylbutanoicacid 95+% ^*data from reagent suppliers

Safty Information:

• Statements: 22-38-40-48/20/22
• Safety Statements: 36/37

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (R)-N-FMOC-alpha-Methylvaline, 98% ee, 98%

There total 6 articles about (R)-N-FMOC-alpha-Methylvaline, 98% ee, 98% which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

(1-hydroxymethyl-1,2-dimethyl-propyl)-carbamic acid 9H-fluoren-9-ylmethyl ester (616867-27-7) → (R)-N2-<(9H-fluoren-9-yl)methoxycarbonyl>-2-methylvaline (616867-28-8)

Guidance literature:

With jones reagent; In acetone; at 20 ℃; for 3h;

DOI:10.1021/ja037078a

Reference yield:

(R)-2-amino-2,3-dimethylbutanoic acid (53940-82-2) + (fluorenylmethoxy)carbonyl chloride (28920-43-6) → (R)-N2-<(9H-fluoren-9-yl)methoxycarbonyl>-2-methylvaline (616867-28-8)

Guidance literature:

With chloro-trimethyl-silane; N-ethyl-N,N-diisopropylamine; Multistep reaction; 1.) CH₂Cl₂, 60 deg C, 1 h, 2.) CH₂Cl₂, 50 deg C, 2 h;

DOI:10.1002/hlca.19950780305

Reference yield:

9-Fluorenylmethanol (24324-17-2) → (R)-N2-<(9H-fluoren-9-yl)methoxycarbonyl>-2-methylvaline (616867-28-8)

Guidance literature:

Multi-step reaction with 3 steps

1: 676 mg / 110 °C

2: 100 percent / HF*pyridine / tetrahydrofuran / 6 h / 20 °C

3: 83 percent / Jones reagent / acetone / 3 h / 20 °C

With jones reagent; pyridine hydrogenfluoride; In tetrahydrofuran; acetone;

DOI:10.1021/ja037078a

upstream raw materials:

(R)-2-amino-2,3-dimethylbutanoic acid

(fluorenylmethoxy)carbonyl chloride

(1-hydroxymethyl-1,2-dimethyl-propyl)-carbamic acid 9H-fluoren-9-ylmethyl ester

9-Fluorenylmethanol

Refernces

• 1、 Obrecht,Bohdal,Broger,Bur,Lehmann,Ruffieux,Schonholzer,Spiegler,Muller. "L-phenylalanine cyclohexylamide: A simple and convenient auxiliary for the synthesis of optically pure α,α-disubstituted (R)- and (S)-amino acids". . p. 563 - 580. Retrieved 2007/10/02.