Cyclopropanecarboxylic acid, 1-amino-2,2-dimethyl-, trimethylsilyl ester (9CI)

Base Information

• Chemical Name: Cyclopropanecarboxylic acid, 1-amino-2,2-dimethyl-, trimethylsilyl ester (9CI)
• CAS No.: 128753-46-8
• Molecular Formula: C₉H₁₉NO₂Si
• Molecular Weight: 201.341
• Mol file: 128753-46-8.mol

Synonyms:Cyclopropanecarboxylic acid, 1-amino-2,2-dimethyl-, trimethylsilyl ester (9CI)

Chemical Property of Cyclopropanecarboxylic acid, 1-amino-2,2-dimethyl-, trimethylsilyl ester (9CI)

Chemical Property:

• PSA: 52.32000
• LogP: 2.19220

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Cyclopropanecarboxylic acid, 1-amino-2,2-dimethyl-, trimethylsilyl ester (9CI)

There total 3 articles about Cyclopropanecarboxylic acid, 1-amino-2,2-dimethyl-, trimethylsilyl ester (9CI) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(N-tert-butylamino)-2,2-dimethylcyclopropane-1-carbonitrile (123445-50-1) → C9H19NO2Si (128753-46-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 2 N aq. hydrogen chloride / 72 h / Heating

2: 0.5 h / 70 °C

With hydrogenchloride;

DOI:10.1021/jo00309a023

Reference yield:

N,O-Bis(trimethylsilyl)trifluoroacetamide (25561-30-2) + (+/-)-2,2-dimethyl-1-aminocyclopropane-1-carboxylic acid (123445-53-4) → C9H19NO2Si (128753-46-8)

Guidance literature:

at 70 ℃; for 0.5h; Yield given;

DOI:10.1021/jo00309a023

Reference yield:

N,O-Bis(trimethylsilyl)trifluoroacetamide (25561-30-2) + (+/-)-2,2-dimethyl-1-aminocyclopropane-1-carboxylic acid (123445-53-4) → C9H19NO2Si (128753-46-8) + C12H27NO2Si2 (128753-48-0)

Guidance literature:

at 70 - 80 ℃; for 0.5h;

DOI:10.1021/jo00102a022

upstream raw materials:

N,O-Bis(trimethylsilyl)trifluoroacetamide

(+/-)-2,2-dimethyl-1-aminocyclopropane-1-carboxylic acid

1-(N-tert-butylamino)-2,2-dimethylcyclopropane-1-carbonitrile

Refernces

• 1、 Kimpe, Norbert De,Sulmon, Paul,Brunet, Pascal. "Synthesis of 2,2-Dialkyl-1-aminocyclopropanecarboxylic Acids from α-Chloro Ketimines". . p. 5777 - 5784. Retrieved 2007/10/02.