4-Amino-6-bromo-2-methylquinoline

Base Information

• Chemical Name: 4-Amino-6-bromo-2-methylquinoline
• CAS No.: 96938-26-0
• Molecular Formula: C₁₀H₉BrN₂
• Molecular Weight: 237.099
• Hs Code.: 2933499090
• European Community (EC) Number: 800-922-0
• DSSTox Substance ID: DTXSID20540110
• Wikidata: Q82415994
• Mol file: 96938-26-0.mol

Synonyms:4-Amino-6-bromo-2-methylquinoline;96938-26-0;6-BROMO-2-METHYLQUINOLIN-4-AMINE;MFCD00814272;Oprea1_251275;SCHEMBL437502;DTXSID20540110;WDA93826;AKOS002331632;AB07349;SY227320;4-Amino-6-bromo-2-methylquinoline, AldrichCPR;G62056;EN300-6744257;Z960971290

Chemical Property of 4-Amino-6-bromo-2-methylquinoline

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 382.206°C at 760 mmHg
• Flash Point: 184.952°C
• PSA: 38.91000
• Density: 1.565g/cm³
• LogP: 3.46910
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 235.99491
• Heavy Atom Count: 13
• Complexity: 186

Purity/Quality:

98%min ^*data from raw suppliers

4-Amino-6-bromo-2-methylquinoline ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22-41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=C2C=C(C=CC2=N1)Br)N

Technology Process of 4-Amino-6-bromo-2-methylquinoline

There total 2 articles about 4-Amino-6-bromo-2-methylquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-bromo-4-hydroxy-2-methylquinoline (103030-28-0) → 6-bromo-2-methyl-[4]quinolylamine (96938-26-0)

Guidance literature:

Multi-step reaction with 2 steps

1: toluene

2: 140 °C

With toluene;

DOI:10.1039/jr9560003293

Reference yield:

6-bromo-4-methoxy-2-methyl-quinoline (103858-51-1) + ammonium acetate (631-61-8,92206-38-7) → 6-bromo-2-methyl-[4]quinolylamine (96938-26-0)

Guidance literature:

at 140 ℃;

DOI:10.1039/jr9560003293

Reference yield: 71.0%

6-bromo-2-methyl-[4]quinolylamine (96938-26-0) + Benzoyl isothiocyanate (532-55-8) → 1-Benzoyl-3-(6-bromo-2-methyl-quinolin-4-yl)-thiourea (96938-60-2)

Guidance literature:

In benzene; for 0.5h; Ambient temperature;

DOI:10.1002/jhet.5570220134

upstream raw materials:

6-bromo-4-methoxy-2-methyl-quinoline

ammonium acetate

6-bromo-4-hydroxy-2-methylquinoline

Downstream raw materials:

1-Benzoyl-3-(6-bromo-2-methyl-quinolin-4-yl)-thiourea