HEMATOXYLIN

Base Information

• Chemical Name: HEMATOXYLIN
• CAS No.: 1412-19-7
• Molecular Formula: C₁₆H₁₄O₆
• Molecular Weight: 302.284
• Mol file: 1412-19-7.mol

Synonyms:AUTOMATION HEMATOXYLIN;DELAFIELD'S HEMATOXYLIN;CI NO 75290;EHRLICH'S HAEMATOXYLIN;EHRLICH'S HEMATOXYLIN;ERLICH'S HAEMATOXYLIN;HEMATOXYLIN ACCORDING TO DELAFIELD;HEMATOXYLIN, DELAFIELD

Chemical Property of HEMATOXYLIN

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Melting Point: 200 °C (dec.)(lit.)
• Boiling Point: 579.876°C at 760 mmHg
• Flash Point: 12 °C
• PSA: 110.38000
• Density: 1.03 g/mL at 20 °C
• LogP: 1.32050

Purity/Quality:

98% ^*data from raw suppliers

Hematoxylin Solution, Harris Modified ^*data from reagent suppliers

Safty Information:

• Pictogram(s): F,Xn,T
• Hazard Codes: F,Xn,T
• Statements: 11-36/37/38-22-39/23/24/25-20/21/22-10
• Safety Statements: 7-16-36-26-24/25-23-45-36/37

MSDS Files:

SDS file from LookChem

Useful:

• Description: As a naturally occurring compound, Haematoxylin is extracted from the heartwood of the logwood tree which is widely used as the basis of a dye in the laboratory all over the world. It was first discovered by Spanish explorers to the Yucatan in 1502 and the hematoxylin-based protocols can date back over one hundred years. Haematoxylin is commonly used in the staining procedures of immunohistochemical (IHC), in which it serves as a counterstain to promote the visualisation and localization of the colored end product of the IHC procedure. It is also widely applied to stain nuclei in microscope slide preparations in histology together with eosin, forming the haematoxylin and eosin stain, which is a permanent stain instead of temporary stains. Besides, it can be applied in the manufacture of ink because of its property.
• Uses: Alum hematoxylin (or hemalum) solutions are used in staining for histology.

Technology Process of HEMATOXYLIN

There total 11 articles about HEMATOXYLIN which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 20.0%

(-)-haematoxylin tetrabenzyl ether (171231-55-3) → hematoxylin (1412-19-7)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethyl acetate; for 24h;

Reference yield:

→ hematoxylin (517-28-2,1621-46-1,17647-60-8,98092-70-7,1412-19-7)

Guidance literature:

With <(1R)-methyloxy->-acetic acid;

DOI:10.1016/0040-4020(70)85029-3

Reference yield:

(6aS,11bR)-7,11b-Dihydro-indeno[2,1-c]chromene-3,4,6a,9,10-pentaol; compound with GENERIC INORGANIC NEUTRAL COMPONENT → Hematoxylin (517-28-2,1412-19-7)

Guidance literature:

In hydrogenchloride; at 30.1 - 60.1 ℃; Equilibrium constant;

upstream raw materials:

(-)-haematoxylin tetrabenzyl ether

3,4-dibenzyloxybenzaldehyde

7,8-dihydroxy-2,3-dihydro-4H-1-benzopyran-4-one

7,8-dihydroxy-3-(3',4'-dihydroxybenzyl)-2,3-dihydro-4H-1-benzopyran-4-one

Downstream raw materials:

C₂₆H₂₄O₅

C₂₇H₂₃F₃O₈S

C₂₆H₂₄O₆

C₂₆H₂₄O₆

Refernces

• 1、 Roubani-Kalantzopoulou, Fani,Katsanos, Nicholas A.. "The Reaction of Hematoxylin with Zirconyl Chloride Studied Spectrophotometrically". . p. 165 - 182. Retrieved 2007/10/02.