Tetrahydro-pyridazine-1,2,3-tricarboxylic acid 1,2-di-tert-butyl ester 3-ethyl ester

Base Information

• Chemical Name: Tetrahydro-pyridazine-1,2,3-tricarboxylic acid 1,2-di-tert-butyl ester 3-ethyl ester
• CAS No.: 336817-83-5
• Molecular Formula: C17H30N2O6
• Molecular Weight: 0
• Mol file: 336817-83-5.mol

Synonyms:Tetrahydro-pyridazine-1,2,3-tricarboxylic acid 1,2-di-tert-butyl ester 3-ethyl ester

Chemical Property of Tetrahydro-pyridazine-1,2,3-tricarboxylic acid 1,2-di-tert-butyl ester 3-ethyl ester

Chemical Property:

• PSA: 85.38000
• LogP: 2.97690

Purity/Quality:

95.0% ^*data from raw suppliers

TETRAHYDRO-PYRIDAZINE-1,2,3-TRICARBOXYLIC ACID-1,2-DI-TERT-BUTYL ESTER-3-ETHYL ESTER 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Tetrahydro-pyridazine-1,2,3-tricarboxylic acid 1,2-di-tert-butyl ester 3-ethyl ester

There total 7 articles about Tetrahydro-pyridazine-1,2,3-tricarboxylic acid 1,2-di-tert-butyl ester 3-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

C18H34N2O9S (1397582-53-4) → N,N'-di-tert-butoxycarbonylpiperazic acid ethyl ester (336817-83-5)

Guidance literature:

With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 2h;

Reference yield:

2-(N,N'-di-tert-butoxycarbonylhydrazino)pent-4-enoic acid ethyl ester (1397581-01-9) → N,N'-di-tert-butoxycarbonylpiperazic acid ethyl ester (336817-83-5)

Guidance literature:

Multi-step reaction with 3 steps

1.1: dimethylsulfide borane complex / tetrahydrofuran / 1.5 h / 0 °C / Inert atmosphere

1.2: 1 h / 0 °C / Inert atmosphere

2.1: dmap; triethylamine / dichloromethane / 2 h / 0 °C / Inert atmosphere

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere

With dmap; dimethylsulfide borane complex; tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.tet.2012.07.014

Reference yield:

2-(N,N'-di-tert-butoxycarbonylhydrazino)-5-hydroxypentanoic acid ethyl ester (1397582-07-8) → N,N'-di-tert-butoxycarbonylpiperazic acid ethyl ester (336817-83-5)

Guidance literature:

Multi-step reaction with 2 steps

1: dmap; triethylamine / dichloromethane / 2 h / 0 °C / Inert atmosphere

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 4 h / 20 °C / Inert atmosphere

With dmap; tetrabutyl ammonium fluoride; triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1016/j.tet.2012.07.014

upstream raw materials:

2-(N,N'-di-tert-butoxycarbonylhydrazino)pent-4-enoic acid ethyl ester

2-(N,N'-di-tert-butoxycarbonylhydrazino)-5-hydroxypentanoic acid ethyl ester

C₁₈H₃₄N₂O₉S

(2-propenyl)propanedioic acid diethyl ester

Downstream raw materials:

N,N'-di-tert-butoxycarbonylpiperazic acid

1,2-di(tert-butoxycarbonyl)-3-(4-bromobenzyl)hexahydropyridazine-3-carboxylic acid ethyl ester

Refernces

• 1、 Duttagupta, Indranil,Goswami, Koushik,Sinha, Surajit. "Synthesis of cyclic α-hydrazino acids". . p. 8347 - 8357. Retrieved 2012/09/21.