6-HydroxyMethyl ExeMestane

Base Information

• Chemical Name: 6-HydroxyMethyl ExeMestane
• CAS No.: 152764-26-6
• Molecular Formula: C₂₀H₂₄O₃
• Molecular Weight: 312.409
• Mol file: 152764-26-6.mol

Synonyms:6-HydroxyMethyl ExeMestane;6-(HydroxyMethyl)androsta-1,4,6-triene-3,17-dione;FCE 27472

Chemical Property of 6-HydroxyMethyl ExeMestane

Chemical Property:

• Melting Point: 198-200°C
• PSA: 54.37000
• LogP: 3.00190
• Storage Temp.: Refrigerator
• Solubility.: Chloroform, Methanol

Purity/Quality:

97% ^*data from raw suppliers

6-HydroxymethylExemestane ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A potential metabolite of Exemestane (E957000).

Technology Process of 6-HydroxyMethyl ExeMestane

There total 4 articles about 6-HydroxyMethyl ExeMestane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 42.0%

FCE27353 (184972-12-1,152764-31-3) → 6-hydroxymethylandrosta-1,4,6-triene-3,17-dione (152764-26-6) + 6α/β-hydroxy-6α/β-hydroxymethylandrosta-1,4-diene-3,17-dione (184972-11-0)

Guidance literature:

With perchloric acid; In tetrahydrofuran; for 3h; Ambient temperature;

DOI:10.1016/0039-128X(93)90029-M

Reference yield:

1-dehydrotestosterone (846-48-0,361432-76-0) → 6-hydroxymethylandrosta-1,4,6-triene-3,17-dione (152764-26-6)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) Me₂NH*HCl / 1.) isoamyl alcohol, reflux, 2 h, 2.) isoamyl alcohol, reflux, 15 h

2: 85 percent / Jones reagent / acetone / 0.25 h / -20 °C

3: 80 percent / 50percent m-chloroperbenzoic acid / CH₂Cl₂ / 48 h / Ambient temperature

4: 38 percent / 20percent aq. HClO₄ / tetrahydrofuran / 3 h / Ambient temperature

With perchloric acid; jones reagent; N,N-dimethylammonium chloride; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; acetone;

DOI:10.1016/0039-128X(93)90029-M

Reference yield:

17β-hydroxy-6-methylen- androsta-1,4-dien-3-one (122370-91-6) → 6-hydroxymethylandrosta-1,4,6-triene-3,17-dione (152764-26-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 85 percent / Jones reagent / acetone / 0.25 h / -20 °C

2: 80 percent / 50percent m-chloroperbenzoic acid / CH₂Cl₂ / 48 h / Ambient temperature

3: 38 percent / 20percent aq. HClO₄ / tetrahydrofuran / 3 h / Ambient temperature

With perchloric acid; jones reagent; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; dichloromethane; acetone;

DOI:10.1016/0039-128X(93)90029-M

upstream raw materials:

FCE₂₇₃₅₃

1-dehydrotestosterone

17β-hydroxy-6-methylen- androsta-1,4-dien-3-one

exemestane

Refernces