1,1-Bis(tosyloxymethyl)cyclopropane

Base Information Edit

Chemical Name:1,1-Bis(tosyloxymethyl)cyclopropane
CAS No.:22308-08-3
Molecular Formula:C19H22O6S2
Molecular Weight:410.512
Hs Code.:2904100000
DSSTox Substance ID:DTXSID40501521
Nikkaji Number:J541.393A
Wikidata:Q82353948
Mol file:22308-08-3.mol

Synonyms:1,1-Bis(tosyloxymethyl)cyclopropane;22308-08-3;[1-[(4-methylphenyl)sulfonyloxymethyl]cyclopropyl]methyl 4-methylbenzenesulfonate;SCHEMBL18047923;DTXSID40501521;(Cyclopropane-1,1-diyl)bis(methylene) bis(4-methylbenzene-1-sulfonate)

Suppliers and Price of 1,1-Bis(tosyloxymethyl)cyclopropane

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 1 raw suppliers

Chemical Property of 1,1-Bis(tosyloxymethyl)cyclopropane Edit

Chemical Property:

PSA：103.50000
LogP:5.35600
XLogP3:3.5
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:8
Exact Mass:410.08578076
Heavy Atom Count:27
Complexity:626

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1=CC=C(C=C1)S(=O)(=O)OCC2(CC2)COS(=O)(=O)C3=CC=C(C=C3)C

Technology Process of 1,1-Bis(tosyloxymethyl)cyclopropane

There total 3 articles about 1,1-Bis(tosyloxymethyl)cyclopropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 39590-81-3
[1-(hydroxymethyl)cyclopropyl]methanol

: 98-59-9
p-toluenesulfonyl chloride

: 22308-08-3
cyclopropane-1,1-diyldimethanediyl bis(4-methylbenzenesulfonate)

Guidance literature:: With potassium hydroxide; In tetrahydrofuran; at 20 ℃; for 12h; Schlenk technique; Inert atmosphere; Cooling with ice;

Reference yield:

: 598-10-7
cyclopropane-1,1-dicarboxylic acid

: 22308-08-3
cyclopropane-1,1-diyldimethanediyl bis(4-methylbenzenesulfonate)

Guidance literature:: Multi-step reaction with 2 steps

1: LiAlH₄ / tetrahydrofuran / 12 h / Heating

2: pyridine / 72 h / 0 °C

With pyridine; lithium aluminium tetrahydride; In tetrahydrofuran;
DOI:10.1021/ja00256a040

Reference yield:

: 1559-02-0
diethyl cyclopropane-1,1-dicarboxylate

: 22308-08-3
cyclopropane-1,1-diyldimethanediyl bis(4-methylbenzenesulfonate)

Guidance literature:: Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 1 h / 0 - 5 °C

2: dmap / dichloromethane / 3 h / 0 - 25 °C

With dmap; lithium aluminium tetrahydride; In tetrahydrofuran; dichloromethane;