N-PHENYLBENZAMIDINE

Base Information

• Chemical Name: N-PHENYLBENZAMIDINE
• CAS No.: 1527-91-9
• Molecular Formula: C13H12N2
• Molecular Weight: 196.252
• Hs Code.: 2925290090
• Mol file: 1527-91-9.mol

Synonyms:Benzamidine,N-phenyl- (6CI,7CI,8CI);N-Phenylbenzamidine;N2-Phenylbenzamidine;NSC 38941;

Chemical Property of N-PHENYLBENZAMIDINE

Chemical Property:

• Vapor Pressure: 5.8E-05mmHg at 25°C
• Melting Point: 117 °C
• Boiling Point: 346.3 °C at 760 mmHg
• PKA: 8.02±0.50(Predicted)
• Flash Point: 163.3 °C
• PSA: 35.88000
• Density: 1.05 g/cm³
• LogP: 3.29680
• Storage Temp.: Inert atmosphere,Room Temperature
• Sensitive.: Hygroscopic

Purity/Quality:

99% ^*data from raw suppliers

N-Phenylbenzamidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R36/37/38:Irritating to eyes, respiratory system and skin.
• Hazard Codes: Xi:Irritant
• Statements: R36/37/38:Irritating to eyes, respiratory system and skin.
• Safety Statements: S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.; S36:Wear suitable prot

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of N-PHENYLBENZAMIDINE

There total 95 articles about N-PHENYLBENZAMIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

C13H12N2O (1266113-09-0) + benzyl chloride (100-44-7) → N-phenylbenzamidine (1527-91-9) + benzaldehyde (100-52-7)

Guidance literature:

C₁₃H₁₂N₂O; benzyl chloride; In diethyl ether; at 20 ℃; for 1h; Inert atmosphere;

With sodium carbonate; In diethyl ether; at 20 ℃; for 3h; Inert atmosphere;

Reference yield: 84.0%

C13H12N2O (1266113-09-0) → N-phenylbenzamidine (1527-91-9) + propionaldehyde (123-38-6)

Guidance literature:

C₁₃H₁₂N₂O; n-propyl halide; In diethyl ether; at 20 ℃; Inert atmosphere;

With sodium carbonate; In diethyl ether; at 20 ℃; Inert atmosphere;

Reference yield: 83.0%

benzonitrile (100-47-0) + aniline (62-53-3) → N2-phenylbenzimidamide (1527-91-9) + 2,4,6-triphenyl-1,3,5-triazine (493-77-6)

Guidance literature:

benzonitrile; With aluminum (III) chloride; at 20 - 100 ℃;

aniline; at 100 ℃; for 4h;

With sodium hydroxide; In water; at 20 ℃;

DOI:10.1016/j.tet.2010.04.103

upstream raw materials:

N-phenyl benzoyl amide

N,N'-diphenylbenzamidine

ammonium benzenesulfonate

N-benzoylbenzamide

Downstream raw materials:

N-benzoyl-N-phenyl-benzamidine

N,N′-dibenzoyl-N-phenylbenzamidine

N-benzoyl-N'-phenyl-benzamidine

N¹-(N-Phenylcarbamoyl)-N²-phenylbenzimidamide

Refernces

• 1、 Soellner, Johannes,Strassner, Thomas. "Phosphorescent Cyclometalated Platinum(II) aNHC Complexes". . p. 15603 - 15612. Retrieved 2018.
• 2、 Charpe, Vaibhav Pramod,Hwang, Kuo Chu,Ragupathi, Ayyakkannu,Sagadevan, Arunachalam. "Photoredox synthesis of functionalized quinazolinesviacopper-catalyzed aerobic oxidative Csp2-H annulation of amidines with terminal alkynes". supporting information. p. 5024 - 5030. Retrieved 2021/07/29.
• 3、 Robertson, Jack,Ungogo, Marzuq A.,Aldfer, Mustafa M.,Lemgruber, Leandro,McWhinnie, Fergus S.,Bode, Bela E.,Jones, Katherine L.,Watson, Allan J. B.,de Koning, Harry P.,Burley, Glenn A.. "Direct, Late-Stage Mono-N-arylation of Pentamidine: Method Development, Mechanistic Insight, and Expedient Access to Novel Antiparastitics against Diamidine-Resistant Parasites". supporting information. p. 3396 - 3401. Retrieved 2021/09/06.