4-Bromo-2,6-difluoroaniline

Base Information

• Chemical Name: 4-Bromo-2,6-difluoroaniline
• CAS No.: 67567-26-4
• Molecular Formula: C6H4BrF2N
• Molecular Weight: 208.005
• Hs Code.: 29214200
• Mol file: 67567-26-4.mol

Synonyms:(4-Bromo-2,6-difluorophenyl)amine;4-Bromo-2,6-difluorobenzenamine;2,6-Difluoro-4-bromoaniline;4-Brom-2,6-difluoranilin;Benzenamine, 4-bromo-2,6-difluoro-;

Chemical Property of 4-Bromo-2,6-difluoroaniline

Chemical Property:

• Vapor Pressure: 0.608mmHg at 25°C
• Melting Point: 63-65 °C(lit.)
• Refractive Index: 1.57
• Boiling Point: 188.2 °C at 760 mmHg
• PKA: 1.11±0.10(Predicted)
• Flash Point: 67.6 °C
• PSA: 26.02000
• Density: 1.788 g/cm³
• LogP: 2.89070
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature

Purity/Quality:

98%, ^*data from raw suppliers

4-Bromo-2,6-difluoroaniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn,Xi
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36-36/37/39-22

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 4-Bromo-2,6-difluoroaniline was used in synthesis of:ammonium 5-bromo-7-fluorobenzo-2-oxa-1,3-diazole-4-sulphonate, fluorogenic derivatizating reagent for the determination of aminothiols by HPLColefin tolanes1-(4-amino-3,5-difluoro)-2-(4-butyloxyphenyl)ethyne4′′-n-butyloxy-3,5-difluoroterphenyl-4-amine4-(3-methylbut-1-yn-3-ol)-2,6-difluoroaniline 4-Bromo-2,6-difluoroaniline is used in the preparation of potent, VEGF receptor tyrosine kinase inhibitors.

Technology Process of 4-Bromo-2,6-difluoroaniline

There total 2 articles about 4-Bromo-2,6-difluoroaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2,6-difluoroaniline (5509-65-9) → 4-bromo-2,6-difluoroaniline (67567-26-4)

Guidance literature:

With N-Bromosuccinimide; In acetonitrile; at 20 ℃;

DOI:10.1002/anie.201509111

Reference yield:

PYRIMIDINE (289-95-2,25247-63-6) + 2,6-difluoroaniline (5509-65-9) → 4-bromo-2,6-difluoroaniline (67567-26-4)

Guidance literature:

With bromine; In chloroform;

Reference yield: 98.0%

methanesulfonyl chloride (124-63-0) + 4-bromo-2,6-difluoroaniline (67567-26-4) → N-(4-bromo-2,6-difluorophenyl)methanesulfonamide (886842-80-4)

Guidance literature:

With pyridine; In tetrahydrofuran; at 20 - 50 ℃; for 6h;

upstream raw materials:

2,6-difluoroaniline

PYRIMIDINE

Downstream raw materials:

1-(4-amino-3,5-difluorophenyl)ethan-1-one

4-bromo-2,6-difluorobenzonitrile

7-benzyloxy-4-(4-bromo-2,6-difluoroanilino)-6-methoxyquinazoline

N,N-dibenzyl-4-bromo-2,6-difluorobenzenamine

Refernces

• 1、 Schultzke, Sven,Staubitz, Anne,Walther, Melanie. "Active ester functionalized azobenzenes as versatile building blocks". supporting information. . Retrieved 2021/07/12.
• 2、 -. "4 - Bromo - 2, 6 - difluoro aniline synthesis method". Paragraph 0022; 0023; 00245; 0005; 00026; 0027; 0028; 0029. . Retrieved 2019/05/15.