Ethyl 3, 5-diMethyl-2-pyridinecarboxylate

Base Information

• Chemical Name: Ethyl 3, 5-diMethyl-2-pyridinecarboxylate
• CAS No.: 80206-41-3
• Molecular Formula: C₁₀H₁₃NO₂
• Molecular Weight: 179.219
• Mol file: 80206-41-3.mol

Synonyms:Ethyl 3, 5-diMethyl-2-pyridinecarboxylate

Chemical Property of Ethyl 3, 5-diMethyl-2-pyridinecarboxylate

Chemical Property:

• PSA: 39.19000
• LogP: 1.87510

Purity/Quality:

97% ^*data from raw suppliers

Ethyl 3 5-dimethyl-2-pyridinecarboxylate95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Ethyl 3, 5-diMethyl-2-pyridinecarboxylate

There total 2 articles about Ethyl 3, 5-diMethyl-2-pyridinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,5-dimethylpicolinic acid (4733-68-0) → 2-(ethoxycarbonyl)-3,5-dimethylpyridine (80206-41-3)

Guidance literature:

With ethanol; Einleiten von HCl;

Reference yield:

ethyl cyanoformate (623-49-4) + prop-1-yne (74-99-7) → 2-(ethoxycarbonyl)-3,5-dimethylpyridine (80206-41-3) + 4,6-dimethylpyridine-2-carboxylic acid ethyl ester (80206-42-4)

Guidance literature:

With aluminum tri-bromide; Yield given. Multistep reaction. Yields of byproduct given; 1.) CH₂Cl₂, -85 deg C, 2.) from -85 to 0 deg C;

DOI:10.1021/jo00345a019

Reference yield:

2-(ethoxycarbonyl)-3,5-dimethylpyridine (80206-41-3) → 3,5-dimethyl-2-propyl-pyridine (142338-60-1)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium ethylate; benzene / Erwaermen mit wss.Salzsaeure

2: aqueous hydrochloric acid; amalgamated zinc

With hydrogenchloride; amalgamated zinc; sodium ethanolate; benzene;

upstream raw materials:

3,5-dimethylpicolinic acid

ethyl cyanoformate

prop-1-yne

Downstream raw materials:

3,5-dimethyl-2-propyl-pyridine

Refernces