Thiophene, 2-[(4-fluorophenyl)Methyl]-5-iodo-

Base Information

• Chemical Name: Thiophene, 2-[(4-fluorophenyl)Methyl]-5-iodo-
• CAS No.: 154355-88-1
• Molecular Formula: C11H8FIS
• Molecular Weight: 318.1490932
• Mol file: 154355-88-1.mol

Synonyms:Thiophene, 2-[(4-fluorophenyl)Methyl]-5-iodo-;2-(4-Fluorobenzyl)-5-iodothiophene;2-[(4-fluorophenyl)methyl]-5-iodothiophene

Chemical Property of Thiophene, 2-[(4-fluorophenyl)Methyl]-5-iodo-

Chemical Property:

• Boiling Point: 333.7±37.0 °C(Predicted)
• PSA: 28.24000
• Density: 1.723±0.06 g/cm3(Predicted)
• LogP: 4.08260

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-[(4-fluorophenyl)methyl]-5-iodothiophene 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Thiophene, 2-[(4-fluorophenyl)Methyl]-5-iodo-

There total 4 articles about Thiophene, 2-[(4-fluorophenyl)Methyl]-5-iodo- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-(4-fluorophenylmethyl)thiophene (63877-96-3) → 5-((4-fluorophenyl)methyl)-2-iodothiophene (154355-88-1)

Guidance literature:

With N-iodo-succinimide; acetic acid; In chloroform; for 1h; Ambient temperature;

DOI:10.1021/jm00024a004

Reference yield:

HIO3 + water (7732-18-5) + 2-(4-fluorophenylmethyl)thiophene (63877-96-3) → 5-((4-fluorophenyl)methyl)-2-iodothiophene (154355-88-1)

Guidance literature:

With I₂; sulfuric acid; acetic acid; In Isopropyl acetate;

Reference yield:

4-Fluorobenzyl bromide (459-46-1) → 5-((4-fluorophenyl)methyl)-2-iodothiophene (154355-88-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) n-butyllithium, 2.) tetrakis(triphenylphosphine)palladium⁽⁰⁾ / 1.) ether, THF, hexane, 0 deg C, 1.5 h, 2.) ether, hexane, THF, RT, overnight

2: 95 percent / N-iodosuccinimide, acetic acid / CHCl₃ / 1 h / Ambient temperature

With N-iodo-succinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; n-butyllithium; acetic acid; In chloroform;

DOI:10.1021/jm00024a004

upstream raw materials:

2-(4-fluorophenylmethyl)thiophene

4-Fluorobenzyl bromide

water

Downstream raw materials:

atreleuton

Refernces

• 1、 -. "Substituted aryl- and heteroarylalkenyl-N-hydroxyurea inhibitors of leukotriene biosynthesis". . . Retrieved 2008/06/13.
• 2、 Brooks,Stewart,Basha,Bhatia,Ratajczyk,Martin,Craig,Kolasa,Bouska,Lanni,Harris,Malo,Carter,Bell. "(R)-(+)-N-[3-[5-[(4-fluorophenyl)methyl]-2-thienyl]-1-methyl-2-propynyl]- N-hydroxyurea (ABT-761), a second-generation 5-lipoxygenase inhibitor". . p. 4768 - 4775. Retrieved 2007/10/03.