2-Bromo-3',5'-difluoro-2'-hydroxyacetophenone, 2-Bromo-1-(3,5-difluoro-2-hydroxyphenyl)ethan-1-one, 2-(Bromoacetyl)-4,6-difluorophenol

Base Information

• Chemical Name: 2-Bromo-3',5'-difluoro-2'-hydroxyacetophenone, 2-Bromo-1-(3,5-difluoro-2-hydroxyphenyl)ethan-1-one, 2-(Bromoacetyl)-4,6-difluorophenol
• CAS No.: 1192815-24-9
• Molecular Formula: C₈H₅BrF₂O₂
• Molecular Weight: 251.027
• Hs Code.: 2914700090
• Mol file: 1192815-24-9.mol

Synonyms:2-Bromo-3',5'-difluoro-2'-hydroxyacetophenone, 2-Bromo-1-(3,5-difluoro-2-hydroxyphenyl)ethan-1-one, 2-(Bromoacetyl)-4,6-difluorophenol;3,5-Difluoro-2-hydroxyphenacyl bromide 95%;3,5-Difluoro-2-hydroxyphenacylbromide95%

Chemical Property of 2-Bromo-3',5'-difluoro-2'-hydroxyacetophenone, 2-Bromo-1-(3,5-difluoro-2-hydroxyphenyl)ethan-1-one, 2-(Bromoacetyl)-4,6-difluorophenol

Chemical Property:

• PSA: 37.30000
• LogP: 2.24800

Purity/Quality:

97% ^*data from raw suppliers

3,5-Difluoro-2-hydroxyphenacyl bromide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Bromo-3',5'-difluoro-2'-hydroxyacetophenone, 2-Bromo-1-(3,5-difluoro-2-hydroxyphenyl)ethan-1-one, 2-(Bromoacetyl)-4,6-difluorophenol

There total 1 articles about 2-Bromo-3',5'-difluoro-2'-hydroxyacetophenone, 2-Bromo-1-(3,5-difluoro-2-hydroxyphenyl)ethan-1-one, 2-(Bromoacetyl)-4,6-difluorophenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(3,5-difluoro-2-hydroxy-phenyl)-ethanone (140675-42-9) → C8H5BrF2O2 (1192815-24-9)

Guidance literature:

With copper(ll) bromide; In ethyl acetate; at 25 ℃; for 10h; Reflux; Inert atmosphere;

DOI:10.1021/acs.joc.8b02857

Reference yield:

C8H5BrF2O2 (1192815-24-9) → 6,8-difluoro-3-(toluene-4-sulfonyl)chroman-4-one

Guidance literature:

Multi-step reaction with 2 steps

1: 1,4-dioxane; water / 3 h / Reflux

2: N-methoxylamine hydrochloride / 15.17 h / 100 °C / Green chemistry

With N-methoxylamine hydrochloride; In 1,4-dioxane; water;

DOI:10.1055/s-0040-1707245

upstream raw materials:

(3,5-difluoro-2-hydroxy-phenyl)-ethanone

Refernces

• 1、 Chang, Meng-Yang,Chen, Han-Yu,Tsai, Yu-Lin. "Temperature-Controlled Desulfonylative Condensation of α-Sulfonyl o-Hydroxyacetophenones and 2-Formyl Azaarenes: Synthesis of Azaaryl Aurones and Flavones". . p. 326 - 337. Retrieved 2019/01/08.