2-QUINOLINECARBONYL CHLORIDE,4-CHLORO

Base Information

• Chemical Name: 2-QUINOLINECARBONYL CHLORIDE,4-CHLORO
• CAS No.: 52144-09-9
• Molecular Formula: C₁₀H₅Cl₂NO
• Molecular Weight: 226.062
• Hs Code.: 2933499090
• Mol file: 52144-09-9.mol

Synonyms:2-QUINOLINECARBONYL CHLORIDE,4-CHLORO

Chemical Property of 2-QUINOLINECARBONYL CHLORIDE,4-CHLORO

Chemical Property:

• PSA: 29.96000
• LogP: 3.26720

Purity/Quality:

99% ^*data from raw suppliers

2-QUINOLINECARBONYL CHLORIDE,4-CHLORO 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-QUINOLINECARBONYL CHLORIDE,4-CHLORO

There total 2 articles about 2-QUINOLINECARBONYL CHLORIDE,4-CHLORO which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-carboxy-4-chloroquinoline (15733-82-1) → 4-Chlor-chinolin-carbonsaeure-(2)-chlorid (52144-09-9)

Guidance literature:

With thionyl chloride; for 4h; Reflux; Inert atmosphere;

DOI:10.1002/ejoc.201600170

Reference yield:

→ 4-Chlor-chinolin-carbonsaeure-(2)-chlorid (52144-09-9)

Guidance literature:

4-Chlor-chinolin-carbonsaeure-(2), SOCl2;

Reference yield:

4-fluorophenyhydrazine hydrochloride (823-85-8) + 4-Chlor-chinolin-carbonsaeure-(2)-chlorid (52144-09-9) → C16H11ClFN3O

Guidance literature:

4-fluorophenyhydrazine hydrochloride; With sodium hydroxide; In dichloromethane; water; at 5 ℃; for 0.333333h;

4-Chlor-chinolin-carbonsaeure-⁽²⁾-chlorid; In dichloromethane; water; at 0 - 20 ℃; for 3.5h;

DOI:10.1021/acs.jafc.1c00670

upstream raw materials:

2-carboxy-4-chloroquinoline

Refernces

• 1、 Yang, Yu-Dong,He, Ying-Hui,Ma, Kun-Yuan,Li, Hu,Zhang, Zhi-Jun,Sun, Yu,Wang, Yu-Ling,Hu, Guan-Fang,Wang, Ren-Xuan,Liu, Ying-Qian. "Design and Discovery of Novel Antifungal Quinoline Derivatives with Acylhydrazide as a Promising Pharmacophore". . p. 8347 - 8357. Retrieved 2021/08/16.