PhthaliMide--d4

Base Information

• Chemical Name: PhthaliMide--d4
• CAS No.: 60161-31-1
• Molecular Formula: C8HD4NO2
• Molecular Weight: 151.155447112
• Mol file: 60161-31-1.mol

Synonyms:PhthaliMide--d4

Chemical Property of PhthaliMide--d4

Chemical Property:

• Storage Temp.: Refrigerator, under inert atmosphere
• Solubility.: DMSO (Sparingly, Heated), Methanol (Slightly, Heated)

Purity/Quality:

97% ^*data from raw suppliers

Phthalimide-d4 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Phthalimide-d4 is the isotope labelled analog of Phthalimide (P384550); a reagent used to transform allyl- and alkyl halides into protected primary amines. Phthalimide analogues have been extensively used in medicinal chemistry owing to their wide spectrum of applications as anti-convulsant, anti-inflammatory, analgesic, hypolipidimic and immunomodulatory activities.

Technology Process of PhthaliMide--d4

There total 1 articles about PhthaliMide--d4 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

phthalic anhydride-d4 (75935-32-9) → 3,4,5,6-tetradeuterophthalimide (60161-31-1)

Guidance literature:

With ammonia; In water; Heating;

DOI:10.1021/jo100858n

Reference yield: 81.0%

3,4,5,6-tetradeuterophthalimide (60161-31-1) → C8H4(2)H4N2O2 (1258840-24-2)

Guidance literature:

With ammonia; In water; at 20 ℃; for 24h;

DOI:10.1021/jo100858n

Reference yield:

3,4,5,6-tetradeuterophthalimide (60161-31-1) → C21H17(2)H4N3O6 (1303947-03-6)

Guidance literature:

Multi-step reaction with 2 steps

1: water / 4 h / 105 °C

2: sulfuric acid / 20 - 50 °C

With sulfuric acid; In water;

DOI:10.1002/jlcr.1847

upstream raw materials:

phthalic anhydride-d₄

Downstream raw materials:

C₈H₄⁽²⁾H₄N₂O₂

C₂₁H₁₇⁽²⁾H₄N₃O₆

Refernces