tert-butyl methyl(3-(methylamino)propyl)carbamate

Base Information

• Chemical Name: tert-butyl methyl(3-(methylamino)propyl)carbamate
• CAS No.: 123183-72-2
• Molecular Formula: C₁₀H₂₂N₂O₂
• Molecular Weight: 202.297
• European Community (EC) Number: 821-984-5
• Mol file: 123183-72-2.mol

Synonyms:tert-butyl methyl(3-(methylamino)propyl)carbamate

Chemical Property of tert-butyl methyl(3-(methylamino)propyl)carbamate

Chemical Property:

• XLogP3: 1
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 6
• Exact Mass: 202.168127949
• Heavy Atom Count: 14
• Complexity: 176

Purity/Quality:

98%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC(C)(C)OC(=O)N(C)CCCNC

Technology Process of tert-butyl methyl(3-(methylamino)propyl)carbamate

There total 4 articles about tert-butyl methyl(3-(methylamino)propyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.9%

C17H28N2O2 (1111237-72-9) → N-(tert-butyl)oxycarbonyl-N,N’-trimethyl-1,3-diaminopropane (123183-72-2)

Guidance literature:

With hydrogen; palladium 10% on activated carbon; In methanol; at 20 ℃;

Reference yield: 82.0%

di-tert-butyl dicarbonate (24424-99-5) + 1,3-bis(methylamino)propane (111-33-1) → N-(tert-butyl)oxycarbonyl-N,N’-trimethyl-1,3-diaminopropane (123183-72-2)

Guidance literature:

In tetrahydrofuran; at 0 - 20 ℃; for 22h; Inert atmosphere;

DOI:10.1002/anie.201916394

Reference yield: 39.0%

methylamine (74-89-5) + methanesulfonic acid 2-(tert-butoxycarbonyl-methyl-amino)propyl ester (273756-96-0) → N-(tert-butyl)oxycarbonyl-N,N’-trimethyl-1,3-diaminopropane (123183-72-2)

Guidance literature:

In ethanol; at 80 ℃; for 12h; Inert atmosphere;

upstream raw materials:

di-tert-butyl dicarbonate

1,3-bis(methylamino)propane

C₁₇H₂₈N₂O₂

methylamine

Downstream raw materials:

C₁₇H₂₆ClN₅O₂

1,3-dimethyl-3,4,5,6-tetrahydro-2(1H)-pyrimidinone

Refernces

• 1、 -. "METHODS AND COMPOUNDS FOR THE TREATMENT OF GENETIC DISEASE". Paragraph 00423; 00481; 00482; 00483. . Retrieved 2021/08/13.
• 2、 -. "IRAK DEGRADERS AND USES THEREOF". Paragraph 00962; 002367; 002370-002371. . Retrieved 2020/06/19.