K-Ras(G12C) inhibitor 9

Base Information

• Chemical Name: K-Ras(G12C) inhibitor 9
• CAS No.: 1469337-91-4
• Molecular Formula: C16H21ClIN3O4S
• Molecular Weight: 513.78
• Mol file: 1469337-91-4.mol

Synonyms:K-Ras(G12C) inhibitor 9;N-[1-[2-[(4-chloro-5-iodo-2-methoxyphenyl)amino]acetyl]-4-piperidinyl]-ethenesulfonamide

Chemical Property of K-Ras(G12C) inhibitor 9

Chemical Property:

• Boiling Point: 656.3±65.0 °C(Predicted)
• PKA: 9.68±0.20(Predicted)
• PSA: 96.12000
• Density: 1.68±0.1 g/cm3(Predicted)
• LogP: 3.90160
• Solubility.: Soluble in DMSO

Purity/Quality:

98%min ^*data from raw suppliers

N-[1-[2-[(4-Chloro-5-iodo-2-methoxyphenyl)amino]acetyl]-4-piperidinyl]ethenesulfonamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Description: K-Ras(G12C) inhibitor 9 is an irreversible, allosteric inhibitor of the K-Ras(G12C) mutant that causes 100% modification of the protein when used at 10 μM for 24 hours in vitro. K-Ras is a small GTPase that cycles between a GTP-bound active state and a GDP-bound inactive state to turn on downstream Raf kinases to drive cell growth. A G12C mutation in K-Ras blocks GTP hydrolysis, activates K-Ras, and promotes carcinogenesis. Similar K-Ras(G12C) inhibitors significantly reduce GTP affinity relative to GDP, decrease Raf binding, and lower cell viability while increasing apoptosis.
• Uses: N-[1-[2-[(4-Chloro-5-iodo-2-methoxyphenyl)amino]acetyl]-4-piperidinyl]ethenesulfonamide is an allosteric inhibitor of tumor-promoting K-Ras(G12c).