5-Ethoxy flavone

Base Information

• Chemical Name: 5-Ethoxy flavone
• CAS No.: 162787-72-6
• Molecular Formula: C₁₇H₁₄O₃
• Molecular Weight: 266.296
• DSSTox Substance ID: DTXSID90440835
• Nikkaji Number: J705.721K
• Wikidata: Q82257268
• ChEMBL ID: CHEMBL358356
• Mol file: 162787-72-6.mol

Synonyms:5-ETHOXY FLAVONE;162787-72-6;5-ethoxy-2-phenyl-4H-chromen-4-one;5-ethoxy-2-phenylchromen-4-one;5-Ethoxyflavone;CHEMBL358356;SCHEMBL9137293;DTXSID90440835

Chemical Property of 5-Ethoxy flavone

Chemical Property:

• PSA: 39.44000
• LogP: 3.85870
• XLogP3: 3.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 266.094294304
• Heavy Atom Count: 20
• Complexity: 382

Purity/Quality:

97% ^*data from raw suppliers

5-ETHOXY FLAVONE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC1=CC=CC2=C1C(=O)C=C(O2)C3=CC=CC=C3

Technology Process of 5-Ethoxy flavone

There total 4 articles about 5-Ethoxy flavone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

5-Hydroxyflavone (491-78-1,66585-06-6) + ethyl iodide (75-03-6) → 5-ethoxy-2-phenyl-4H-chromen-4-one (162787-72-6)

Guidance literature:

With potassium carbonate; In acetone; for 6h; Heating;

DOI:10.1021/jm00025a011

Reference yield:

2-hydroxy-1-(2-hydroxyphenyl)ethanone (17375-96-1) → 5-ethoxy-2-phenyl-4H-chromen-4-one (162787-72-6)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / acetone / 12 h / 55 °C

2: sulfuric acid / 4 h / Cooling with ice

3: potassium carbonate / dichloromethane / 20 °C

With sulfuric acid; potassium carbonate; In dichloromethane; acetone;

Reference yield:

benzoyl chloride (98-88-4) → 5-ethoxy-2-phenyl-4H-chromen-4-one (162787-72-6)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / acetone / 12 h / 55 °C

2: sulfuric acid / 4 h / Cooling with ice

3: potassium carbonate / dichloromethane / 20 °C

With sulfuric acid; potassium carbonate; In dichloromethane; acetone;

upstream raw materials:

5-Hydroxyflavone

ethyl iodide

2-hydroxy-1-(2-hydroxyphenyl)ethanone

benzoyl chloride

Refernces

• 1、 -. "Flavonoid compound as well as preparation method and application thereof". Paragraph 0053-0054; 0057. . Retrieved 2021/10/20.