1-(5-bromopyridin-2-yl)cyclobutanecarboxylic acid

Base Information

• Chemical Name: 1-(5-bromopyridin-2-yl)cyclobutanecarboxylic acid
• CAS No.: 1382486-27-2
• Molecular Formula: C10H10BrNO2
• Molecular Weight: 256.099
• Mol file: 1382486-27-2.mol

Synonyms:1-(5-bromopyridin-2-yl)cyclobutanecarboxylic acid

Chemical Property of 1-(5-bromopyridin-2-yl)cyclobutanecarboxylic acid

Chemical Property:

• Boiling Point: 381.3±37.0 °C(Predicted)
• PKA: 3.20±0.20(Predicted)
• PSA: 50.19000
• Density: 1.649±0.06 g/cm3(Predicted)
• LogP: 2.35040
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

1-(5-Bromopyridin-2-Yl)CyclobutanecarboxylicAcid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(5-bromopyridin-2-yl)cyclobutanecarboxylic acid

There total 5 articles about 1-(5-bromopyridin-2-yl)cyclobutanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(5-bromopyridin-2-yl)cyclobutane-1-carbonitrile (485828-81-7) → 1-(5-bromopyridin-2-yl)cyclobutanecarboxylic acid (1382486-27-2)

Guidance literature:

With sulfuric acid; acetic acid; In water; at 85 ℃; for 3h;

Reference yield:

methyl 4-(5-bromopyridin-2-yl)oxane-4-carboxylate: (1382486-55-6) → 1-(5-bromopyridin-2-yl)cyclobutanecarboxylic acid (1382486-27-2)

Guidance literature:

methyl 4-(5-bromopyridin-2-yl)oxane-4-carboxylate:; With water; lithium hydroxide; In tetrahydrofuran; methanol;

With hydrogenchloride; In water; ethyl acetate;

Reference yield:

cyclobutanecarbonitrile (4426-11-3) → 1-(5-bromopyridin-2-yl)cyclobutanecarboxylic acid (1382486-27-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: diisopropylamine; n-butyllithium / tetrahydrofuran / 0.67 h / -78 °C

1.2: 18 h / 20 °C

2.1: sodium hydroxide; water / ethanol / 18 h / 85 °C / Inert atmosphere

With n-butyllithium; water; diisopropylamine; sodium hydroxide; In tetrahydrofuran; ethanol;

upstream raw materials:

2,5-dibromopyridine

cyclobutanecarbonitrile

1-(5-bromopyridin-2-yl)cyclobutane-1-carbonitrile

methyl 4-(5-bromopyridin-2-yl)oxane-4-carboxylate:

Refernces

• 1、 -. "PICOLINAMIDE COMPOUNDS". Paragraph 00165. . Retrieved 2019/05/10.
• 2、 -. "BIARYLAMIDE INHIBITORS OF LEUKOTRIENE PRODUCTION". . . Retrieved 2012/06/30.