Sodium 4-aminosalicylate

Base Information

• Chemical Name: Sodium 4-aminosalicylate
• CAS No.: 133-10-8
• Deprecated CAS: 8031-28-5,857363-33-8,1081807-72-8
• Molecular Formula: C7H6NNaO3
• Molecular Weight: 175.119
• Hs Code.: 2918219000
• European Community (EC) Number: 205-091-2,682-416-8
• UNII: T9ZKL3TNQF
• DSSTox Substance ID: DTXSID0046066
• Wikidata: Q27105758
• NCI Thesaurus Code: C47958
• ChEMBL ID: CHEMBL1200966
• Mol file: 133-10-8.mol

Synonyms:Sodium 4-aminosalicylate;133-10-8;sodium 4-amino-2-hydroxybenzoate;Sodium p-aminosalicylate;p-Aminosalicylic acid sodium salt;AMINOSALICYLATE SODIUM;Sodium PAS;p-Aminosalicylate sodium;Bactylan;Sanipirol;Tubersan;Lepasen;Pamisyl sodium;Aminosalicylate sodium anhydrous;Passodico;Sodiopas;Nippas;Pasade;Pasnal;Salvis;Sodium aminosalicylate;Pasalon-rakeet;Natri-pas;4-AMINOSALICYLIC ACID SODIUM SALT;Sodium p-aminosalicylic acid;PAS-Na;Benzoic acid, 4-amino-2-hydroxy-, monosodium salt;Sodium4-Aminosalicylate;sodium;4-amino-2-hydroxybenzoate;8031-28-5;Monosodium 4-amino-2-hydroxybenzoate;Monosodium T4-amino-2-hydroxybenzoate;4-Amino-2-hydroxybenzoic acid sodium salt;T9ZKL3TNQF;UNII-T9ZKL3TNQF;EINECS 205-091-2;C7H6NO3.Na;Aminosalicylate sodium anhydrous [USAN];MLS000069500;CHEBI:2661;DTXSID0046066;Sodium 2-hydroxy-4-aminobenzoate;Neopasalate;Salicylic acid, 4-amino-, sodium salt;SMR000058602;SODIUM P.A.S;TEEBACIN;DTXCID8026066;P.A.S. SODIUM;Aminosalicylate Sodium [USAN];CAS-133-10-8;p-Aminosalicylic Acid Monosodium Salt;NCGC00159472-02;p-Aminosalicylate acid sodium salt dihydrate;Monopas;sodium,4-amino-2-hydroxybenzoate;sodium 4-amino-2-hydroxy-benzoate;sodium p aminosalicylate;4-aminosalicylate sodium;Opera_ID_136;para-aminosalicylate sodium;C7H7NO3.Na;C7H6NO3.2H2O.Na;SCHEMBL688206;SPECTRUM1500116;CHEMBL1200966;FVVDKUPCWXUVNP-UHFFFAOYSA-M;HMS1920C11;HMS2091I11;HMS2230H22;HMS3371F03;HMS3652I08;Aminosalicylate Sodium (anhydrous);sodium 4-azanyl-2-oxidanyl-benzoate;Tox21_111696;MFCD00064392;s4073;AKOS006229752;AKOS015963386;ANHYDROUS SODIUM AMINOSALICYLATE;SODIUM AMINOSALICYLATE [MART.];Tox21_111696_1;AMINOSALICYLATE SODIUM [WHO-DD];CCG-212479;NCGC00094584-01;NCGC00094584-02;NCGC00159472-05;AC-19339;AC-32474;LS-144250;LS-176072;A0423;CS-0009515;FT-0617610;SW219149-1;C08055;EN300-384272;ANHYDROUS SODIUM AMINOSALICYLATE [MART.];A806557;p-Aminosalicylic Acid, Monosodium Salt, Dihydrate;Q27105758;F1905-7106

Chemical Property of Sodium 4-aminosalicylate

Chemical Property:

• Appearance/Colour: white crystalline
• Vapor Pressure: 1.78E-06mmHg at 25°C
• Melting Point: 150-151oC, with effervescence
• Boiling Point: 380.8 °C at 760 mmHg
• Flash Point: 184.1 °C
• PSA: 86.38000
• Density: 1.491g/cm3
• LogP: -0.08090
• Storage Temp.: Sealed in dry,Room Temperature
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 1
• Exact Mass: 175.02453734
• Heavy Atom Count: 12
• Complexity: 165

Purity/Quality:

99% ^*data from raw suppliers

p-AMINOSALICYLICACIDSODIUMSALTDIHYDRATE Approx.99% ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=C(C=C1N)O)C(=O)[O-].[Na+]

Technology Process of Sodium 4-aminosalicylate

There total 3 articles about Sodium 4-aminosalicylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

→ sodium p-aminosalicylate (133-10-8)

Guidance literature:

Reference yield:

4-Aminosalicylic acid (65-49-6) → sodium p-aminosalicylate (133-10-8)

Guidance literature:

With sodium carbonate;

DOI:10.1039/c2ce05771a

Reference yield:

cytosinium 4-aminosalicylate (65944-71-0) → sodium p-aminosalicylate (133-10-8)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol / Milling

2: sodium hydroxide / water / 20 °C

With sodium hydroxide; In ethanol; water;

DOI:10.1021/cg301798s

upstream raw materials:

4-Aminosalicylic acid

cytosinium 4-aminosalicylate

Downstream raw materials:

2,2'-dihydroxy-4,4'-ureylene-di-benzoic acid

4-ethoxycarbonylamino-2-hydroxy-benzoic acid

2-hydroxy-4-(N'-phenyl-thioureido)-benzoic acid

2-Hydroxy-4-(2-{N'-[1-(2-hydroxy-phenyl)-meth-(Z)-ylidene]-hydrazino}-4-phenyl-selenazol-5-ylazo)-benzoic acid

Refernces

• 1、 Cherukuvada, Suryanarayan,Bolla, Geetha,Sikligar, Kanishka,Nangia, Ashwini. "4-aminosalicylic acid adducts". . p. 1551 - 1557. Retrieved 2013/05/21.