VER-50589

Base Information

• Chemical Name: VER-50589
• CAS No.: 747413-08-7
• Molecular Formula: C₁₉H₁₇ClN₂O₅
• Molecular Weight: 388.807
• Hs Code.: 2934999090
• Mol file: 747413-08-7.mol

Synonyms:VER-50589;5-(5-chloro-2,4-dihydroxyphenyl)-N-ethyl-4-(4-Methoxyphenyl)isoxazole-3-carboxaMide;5-(5-Chloro-2,4-dihydroxyphenyl)-N-ethyl-4-(4-methoxyphenyl)-3-isoxazolecarboxamide

Chemical Property of VER-50589

Chemical Property:

• Boiling Point: 583.0±50.0 °C(Predicted)
• PKA: 7.12±0.25(Predicted)
• PSA: 104.82000
• Density: 1.360±0.06 g/cm3(Predicted)
• LogP: 4.22240
• Solubility.: ≥38.9 mg/mL in DMSO; insoluble in H2O; ≥57.2 mg/mL in EtOH

Purity/Quality:

98% min ^*data from raw suppliers

VER-50589 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: VER-50589 inhibits the intrinsic ATPase activity of recombinant yeast Hsp90. It produces antiproliferative activity in a panel of human cancer cell lines and nontumorigenic cells in vitro.

Technology Process of VER-50589

There total 1 articles about VER-50589 which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

3-(2,4-bis-benzyloxy-5-chloro-phenyl)-4-(4-methoxy-phenyl)-isoxazole-3-carboxylic acid ethylamide → VER 50589 (747413-08-7)

Guidance literature:

3-(2,4-bis-benzyloxy-5-chloro-phenyl)-4-(4-methoxy-phenyl)-isoxazole-3-carboxylic acid ethylamide; With boron trichloride; In dichloromethane; at 0 - 20 ℃; for 0.833333h;

With sodium hydrogencarbonate; In dichloromethane; water; at 0 ℃; for 0.0833333h;

Refernces

• 1、 -. "ISOXAZOLE COMPOUNDS AS INHIBITORS OF HEAT SHOCK PROTEINS". Page 47; 48. . Retrieved 2010/02/08.