2-(2-Ethoxyphenyl)ethanol

Base Information

• Chemical Name: 2-(2-Ethoxyphenyl)ethanol
• CAS No.: 22545-14-8
• Molecular Formula: C10H14 O2
• Molecular Weight: 166.22
• NSC Number: 71560
• DSSTox Substance ID: DTXSID20290865
• Wikidata: Q82028664
• Mol file: 22545-14-8.mol

Synonyms:2-(2-ethoxyphenyl)ethanol;22545-14-8;2-(2-ethoxyphenyl)ethan-1-ol;2-ethoxyphenethyl alcohol;Benzeneethanol,2-ethoxy-;NSC71560;NCIOpen2_000540;SCHEMBL3025752;DTXSID20290865;NSC 71560;NSC-71560;AKOS012095956;SB85143;CS-0299495;FT-0726872;C78071;EN300-1624063

Chemical Property of 2-(2-Ethoxyphenyl)ethanol

Chemical Property:

• Vapor Pressure: 0.00588mmHg at 25°C
• Boiling Point: 261.4°Cat760mmHg
• Flash Point: 106.5°C
• PSA: 29.46000
• Density: 1.037g/cm³
• LogP: 1.62010
• XLogP3: 2.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 166.099379685
• Heavy Atom Count: 12
• Complexity: 114

Purity/Quality:

99%min ^*data from raw suppliers

2-(2-ETHOXYPHENYL)ETHAN-1-OL ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC1=CC=CC=C1CCO

Technology Process of 2-(2-Ethoxyphenyl)ethanol

There total 7 articles about 2-(2-Ethoxyphenyl)ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

oxirane (75-21-8,99932-75-9) + beta-bromophenetole (583-19-7) → 2-(2-ethoxyphenyl)ethanol (22545-14-8)

Guidance literature:

beta-bromophenetole; With iodine; magnesium; In tetrahydrofuran; at 0 ℃; for 0.5h; Inert atmosphere; Reflux;

oxirane; In tetrahydrofuran; at 20 ℃;

Reference yield:

2-(2-hydroxyphenyl)ethanol (7768-28-7) + ethyl iodide (75-03-6) → 2-(2-ethoxyphenyl)ethanol (22545-14-8)

Guidance literature:

With sodium ethanolate;

Reference yield:

methyl 2-(ethoxyphenyl)acetate (186019-68-1) → 2-(2-ethoxyphenyl)ethanol (22545-14-8)

Guidance literature:

With sodium tetrahydroborate; In tetrahydrofuran; methanol; at 20 ℃; for 16h; Reflux;

DOI:10.1016/j.bmcl.2016.12.007

upstream raw materials:

2-ethoxyphenylmagnesium bromide

2-(2-hydroxyphenyl)ethanol

ethyl iodide

1-benzofurane

Downstream raw materials:

1-ethoxy-2-(2-iodoethyl)benzene

ethoxyphenethyl bromide

Refernces

• 1、 -. "ACC INHIBITORS AND USES THEREOF". . . Retrieved 2013/05/22.