1-(phenylsulfanyl)cyclopentanecarbonitrile

Base Information

• Chemical Name: 1-(phenylsulfanyl)cyclopentanecarbonitrile
• CAS No.: 36638-54-7
• Molecular Formula: C12H13NS
• Molecular Weight: 203.308
• Mol file: 36638-54-7.mol

Synonyms:

Chemical Property of 1-(phenylsulfanyl)cyclopentanecarbonitrile

Chemical Property:

• Vapor Pressure: 2.61E-05mmHg at 25°C
• Boiling Point: 358.1°Cat760mmHg
• Flash Point: 170.3°C
• Density: 1.14g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-(phenylsulfanyl)cyclopentanecarbonitrile

There total 2 articles about 1-(phenylsulfanyl)cyclopentanecarbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

cyclopentanecarbonitrile (4254-02-8) + diphenyldisulfane (882-33-7) → 1-(phenylthio)cyclopentanecarbonitrile (36638-54-7)

Guidance literature:

cyclopentanecarbonitrile; With lithium diisopropyl amide; In tetrahydrofuran; at -78 ℃; for 0.75h;

diphenyldisulfane; In tetrahydrofuran; at -78 - 20 ℃; for 3h;

DOI:10.1002/anie.201105630

Reference yield:

(phenylthio)acetonitrile (5219-61-4) + 1,4-dichlorobutane (110-56-5) → 1-(phenylthio)cyclopentanecarbonitrile (36638-54-7)

Guidance literature:

With sodium hydroxide; N-benzyl-N,N,N-triethylammonium chloride;

DOI:10.1016/S0040-4039(01)85311-9

Reference yield: 100.0%

1-(phenylthio)cyclopentanecarbonitrile (36638-54-7) → 1-(phenylsulfinyl)cyclopentanecarbonitrile (1360557-42-1)

Guidance literature:

With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at -78 ℃; for 0.0833333h;

DOI:10.1002/anie.201105630

upstream raw materials:

(phenylthio)acetonitrile

1,4-dichlorobutane

cyclopentanecarbonitrile

diphenyldisulfane

Downstream raw materials:

1-(phenylsulfinyl)cyclopentanecarbonitrile

1-benzylcyclopentane-1-carbonitrile

Refernces

• 1、 Nath, Dinesh,Fleming, Fraser F.. "Sulfinylnitriles: Sulfinyl-metal exchange-alkylation strategies". supporting information. p. 2023 - 2029. Retrieved 2013/03/14.