1-Phenylazulene

Base Information

• Chemical Name: 1-Phenylazulene
• CAS No.: 7206-60-2
• Molecular Formula: C16H12
• Molecular Weight: 204.271
• Mol file: 7206-60-2.mol

Synonyms:1-Phenylazulene

Chemical Property of 1-Phenylazulene

Chemical Property:

• PSA: 0.00000
• LogP: 4.45840

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Phenylazulene

There total 29 articles about 1-Phenylazulene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 59.0%

1-(azulen-1-yl)tetrahydrothiophenium hexafluorophosphate + phenylboronic acid (98-80-6) → 1-Phenylazulene (7206-60-2)

Guidance literature:

With potassium phosphate; palladium diacetate; XPhos; In N,N-dimethyl-formamide; at 75 ℃; for 6h; Inert atmosphere;

DOI:10.1021/acs.joc.0c01412

Reference yield: 40.6%

(E)-1-styrylpyrrolidine (6908-73-2,13294-34-3) + cyclohepta[b]furan-2(2H)-one (4481-35-0) → 1-Phenylazulene (7206-60-2)

Guidance literature:

In ethanol; for 6h; Heating;

DOI:10.1246/cl.1980.579

Reference yield: 13.0%

iodobenzene (591-50-4) + azulene (275-51-4) → 1-Phenylazulene (7206-60-2)

Guidance literature:

With tetrabutylammomium bromide; potassium carbonate; palladium diacetate; In N,N-dimethyl-formamide; at 100 ℃; for 72h; Further Variations:; Reaction partners; Reagents; Temperatures; reaction partner and catalyst equivalents; Product distribution;

DOI:10.1016/S0022-328X(00)00224-2

upstream raw materials:

methanol

N-nitrosoacetanilide

sodium acetate

benzene

Downstream raw materials:

C₂₄H₁₇N

Refernces

• 1、 Plattner et al.. "-". . p. 1910,1916. Retrieved 1950.
• 2、 Crombie, Aimee L.,Kane Jr., John L.,Shea, Kevin M.,Danheiser, Rick L.. "Ring expansion-annulation strategy for the synthesis of substituted azulenes and oligoazulenes. 2. Synthesis of azulenyl halides, sulfonates, and azulenylmetal compounds and their application in transition-metal-mediated coupling reactions". . p. 8652 - 8667. Retrieved 2007/10/03.