1-Ethylpiperidin-3-amine

Base Information

• Chemical Name: 1-Ethylpiperidin-3-amine
• CAS No.: 6789-94-2
• Molecular Formula: C7H16N2
• Molecular Weight: 128.217
• Hs Code.: 2933399090
• European Community (EC) Number: 229-857-0
• NSC Number: 76077
• DSSTox Substance ID: DTXSID40871170
• Nikkaji Number: J143.132C
• Mol file: 6789-94-2.mol

Synonyms:1-ethylpiperidin-3-amine;6789-94-2;3-Amino-N-ethylpiperidine;3-Piperidinamine, 1-ethyl-;Piperidine, 3-amino-1-ethyl-;1-Ethyl-piperidin-3-ylamine;3-Amino-1-ethylpiperidine;NSC 76077;N-Ethyl-3-aminopiperidine;EINECS 229-857-0;MFCD00044587;AI3-52444;1-Ethyl-3-piperidinamine;1-ETHYL-3-PIPERIDINEAMINE;NSC76077;Ethyl-3-amino-piperidin;3-amino--ethylpiperidine;3-amino-N-ethylpiperdine;1-ethylpiperidine-3-amine;1-ethylpiperidin-3-ylamine;1-ethyl-3-amino-piperidine;3-amino-1-ethyl-piperidine;1-Ethyl-3-piperidinamine #;SCHEMBL178341;DTXSID40871170;3-nitroadamantane-1-carboxylicacid;HMS1704K13;NSC-76077;STK691766;3-amino-N-ethylpiperidine, AldrichCPR;AKOS000745895;AKOS016346157;AT32251;SB41229;LS-06011;CS-0030177;FT-0636259;EN300-52215;Z736883394

Chemical Property of 1-Ethylpiperidin-3-amine

Chemical Property:

• Vapor Pressure: 3.08mmHg at 25°C
• Refractive Index: 1.465
• Boiling Point: 155.1 °C at 760 mmHg
• PKA: 11.06±0.20(Predicted)
• Flash Point: 60.6 °C
• PSA: 29.26000
• Density: 0.898 g/cm³
• LogP: 1.06760
• Storage Temp.: -20°C Freezer
• Solubility.: Methanol
• XLogP3: 0.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 128.131348519
• Heavy Atom Count: 9
• Complexity: 83

Purity/Quality:

99.5% ^*data from raw suppliers

1-Ethyl-3-piperidinamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 22-37/38-41
• Safety Statements: 26-39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCN1CCCC(C1)N
• Uses: 1-Ethyl-3-piperidinamine is an intermediate in the synthesis of 4-Amino-N-(1-ethyl-3-piperidinyl)-5-(ethylsulfonyl)-2-methoxybenzamide (A609495), which is an impurity of Amisulpride (A633250). Amisulpride EP Impurity G.

Technology Process of 1-Ethylpiperidin-3-amine

There total 5 articles about 1-Ethylpiperidin-3-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(1-ethyl-[3]piperidyl)-acetamide (24059-81-2) → 1-ethylpiperidin-3-amine (6789-94-2)

Guidance literature:

With hydrogenchloride; at 100 ℃; for 14h;

Reference yield:

→ 1-ethylpiperidin-3-amine (6789-94-2)

Guidance literature:

With potassium hydroxide; bromine;

Reference yield:

1-Ethyl-piperidin-3-one oxime (213627-39-5) → 1-ethylpiperidin-3-amine (6789-94-2)

Guidance literature:

With sodium bis(2-methoxyethoxy)aluminium dihydride;

DOI:10.1016/S0960-894X(98)00341-2

upstream raw materials:

1-Ethyl-piperidin-3-one oxime

N-(1-ethyl-[3]piperidyl)-acetamide

Downstream raw materials:

7-Chloro-3-(3,4-dichloro-phenyl)-1-[(E)-1-ethyl-piperidin-3-ylimino]-10-hydroxy-1,3,4,10-tetrahydro-2H-acridin-9-one

N-(1-ethyl-piperidin-3-yl)-2-methoxy-5-sulfamoyl-benzamide

N-(1-Ethyl-piperidin-3-yl)-2-methoxy-5-nitro-benzamide

N-(4-Chloro-phenyl)-N'-[4-(1-ethyl-piperidin-3-ylamino)-6-trichloromethyl-[1,3,5]triazin-2-yl]-guanidine

Refernces

• 1、 Hirokawa, Yoshimi,Yamazaki, Hiroshi,Yoshida, Naoyuki,Kato, Shiro. "A novel series of 6-methoxy-1H-benzotriazole-5-carboxamide derivatives with dual antiemetic and gastroprokinetic activities". . p. 1973 - 1978. Retrieved 2007/10/03.